Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

The Effect of LR3 Acupuncture on Blood Pressure and C-fos Expression in Hypertensive Rats Induced by 2K1C

침자(鍼刺)가 혈압(血壓) 및 신경계(神經系) 혈압중추(血壓中樞) c-fos 발현에 미치는 영향(影響)

  • Kang Dong-Hwan (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Yun Yeo-Chung (Dept. of Acupucture & Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Kim Jeong-Sang (Dept. of Anatomy, College of Oriental Medicine, Dongshin University) ;
  • Kim Won-Jae (Dept. of Oral Physiology, College of dentistry, Chonnam National University) ;
  • Na Chang-Su (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongshin University)
  • 강동환 (동신대학교 한의과대학 경혈학교실) ;
  • 윤여충 (동신대학교 한의과대학 침구학교실) ;
  • 김정상 (동신대학교 한의과대학 해부학교실) ;
  • 김원재 (전남대학교 치과대학 생리학교실) ;
  • 나창수 (동신대학교 한의과대학 경혈학교실)
  • Published : 2002.03.27
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Abstract

The frequency of the hypertension is increasing as the life level is improved and an average span of the life is extended since we approached modern stage. The hypertension is also dangerous disease which raises fatal complication for example with the bleeding aproplexy and the ischemic attack. The medicinal treatment about the hypertension is required patients to take continually. The acupuncture have been introduced because a medicine-chemical treatment hasn't good influence on the human body. It recently has been processed that studies acupuncture effect for blood pressure and have been found out that blood pressure go down. The object of this study observe the effect of LR3 acupuncture on hypertension in Renal Hypertension RAT induced by 2K1C. The 2K1C model was based on renin-angiotensin system. We put the silver clip in renal artery to induce renal hypertension. We try to observe that LR3 acupuncture influence on the blood pressure and c-fos expression in CVLM, NTS, RVLM. In results, the blood pressure was decreased during acupuncture than before acupuncture, after acupuncture. The heart rate was also decreased during acupuncture than before acupuncture, after acupuncture. The LR3 acupuncture significantly effects on blood pressure and heart rate (P<0.05). The increased expression of c-fos was shown in CVLM, NTS, but not in RVLM. In conclusion, LR3 was relived the action of control upon the hypertension and related with medulla, particularly CVLM, NTS. It needs to be closely examined pharmacological mechanism and studied combination with other acupoints.

Keywords

References

  1. Hypertension v.26 Cardiovascular and respiratory effects of endothelin in the ventrolateral medulla of the normotensive rat. Garcia RM;Yates K;O'Leary J;Inagami T
  2. 대한의학협회지 v.36 no.11 高血壓基準과治療의 最近 方向 吳秉熙
  3. Zhongguo Zhong Xi Yi Jie He Za Zhi v.18 no.1 Ambulatory monitoring of blood pressure in the evluation of eficacy of acupunct;ure therapy of hypertension Dan Y
  4. Lik Sprays no.1 Acupuncture reflexotherapy in the treatment of hypertension patients. Babichenko MA
  5. J Tradit Chin Med v.10 no.4 Clinical observation on the immediate hypotensive effect of zanzhu point. Yao W;Liu H
  6. Auton Neurosci. v.89 no.1;2 Restral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats. Li P;Tjens-A-Looi S ;Longhurst JC
  7. Jpn J Physiol v.51 no.2 Cardiovascular beneficial effects ofelectroacupuncture at Neiguan (PC-6)acupoint in anesthetized open-chest dog. Syuu Y, Matsubara H, Kiyooka T, Hosogi5, Mohri 5, Araki J, Ohe T, Suga H
  8. J Hum Hypertens v.14 no.12 The effectof transcutaneous electric nerve stimulation in patients with therapy-resistant hypertension. Jacobsson F;Himmelmann A;BergbrantA;Svensson A;Mannheimer C
  9. Am J Chin Med. v.25 no.1 Effects of moxibustion on blood pressure and renal function in spontaneously hypertensive rats. Lee HS;Yu YC;Kim ST;Kim KS
  10. Phys Ther v.71 no.7 Effect of acupuncture-point stimulation on diastolic blood pressure in hypertensive subjects. Williams T;Mueller K;Cornwall MW
  11. 대한침구학회지 v.16 no.2 고혈압치료에 상용되는 체간부 경혈에 대한 형태학적 연구 이창현;이상용;변덕시
  12. 實用中西醫結合診斷治療學 v.7 陳貴廷;楊思潛
  13. 중국침구혈위통감 왕덕심
  14. BMJ v.289 Effects of treatment for hype 티ension on cerebral hemorrhage and infarction. Black DG;Meagerly AM;Bing RF;Thurston H;Swales JD.
  15. Stroke v.19 no.4 Hypertension managementand stroke recurrence in a community(Rochester, Minnesota, 1950-1979).. Irene Meissner;Whisnant JP;MichaelGarraway W
  16. Greenfield's Neuropathology Patitologic changes in the brain in hypertension hume Adams J;Duchen LW
  17. Stroke Pathology Diagnosisand Management. Henry JM;Barnett;Mohr JP;Stein BM;Yatsu FM
  18. 鐵美擧(上). 全國韓醫科大學 .鐵集經穴學敎室(編著)
  19. 黃帝內經靈襤校注語釋 潛飜春
  20. 鐵美甲乙經校釋 山車中醫學院
  21. 經穴學各論 縱昌株
  22. 殷史 生理學 김정진
  23. Hypertension v.27 no.3 Alltered c-fos i n rostral medulla and spinal cord of spontaneously hypertensive rats. Minson J;Arnolda L;Smith IL;Pilowsky P;Cahlmers J
  24. Brain Res. v.646 no.1 Disinhiibition of the rostral ventral medulla increases blood pressure and Fos expression in bulbospinal neurons. Minson JB;Liewellyn-Smith IJ;Arnolda LF;Pilowsky PM;Oliver JR;Chalmers JP
  25. BrainRes. v.506 Cardiovascular effects of L-glutamate and tetrodotoxin microiniected into the rostral and caudal ventrolaral medullla innormotensive and spontaneously hypertensive rats. Smith JK;Barron KW
  26. Brain Res. v.592 no.1;2 Tonic stimulation of GABAB receptors in the nucleus tractus solitarius modulates the baroreceptor reflex. Sved AF;Tsukamoto K
  27. Hypertension v.22 Enhanced γ-aminobufric acidmediated responses in nucleus tractus solitarius of hypertensive rats. Tsukamoto K;Sved AF
  28. Hypertension v.27 Role of γ -aminobutyrie acid B receptor in barrorceptor reflex in hypertensive rats. Yin M;Sved AF
  29. clin. and exper. Hypertension. v.19 no.5;6 C-fos expression in central neuron Emediating the arterial baroreceptor reflex. J.B.Minson;IJ Llewellyn-Smith; LF Anolda;PM Piloweky;JP Chanlmers
  30. clin. and exper. Hypertension. v.18 no.3;4 Imediate early genes in blooe pressure regulation. JB Mnson;LF Arnolda;IJ Llewellyn Smith;PM Pilowsky;S Suzuki;JP Chalmers
  31. Virology v.116 Identification of a 39,000 dalton protein in cells transformed by the FBJ murine osteosauoma virus. Curran T;Teich NM
  32. Molecular Neurobiology Fos-Jun and primary genomic response in the nervous system : Possible physiological role and pathophysiological significance. Doucet SP;Squinto SP;Bazan NG
  33. Neuron v.6 Molecular pathways of pain ;FosserotoninJun-mediated activation of a non canocical AP-1site in the prodynorphin gene. Naarnjo JR;Bellstrom B;Achabal M;Sassone-corsi P
  34. Science v.246 Regulation of proenkphalin by Fos and Jun Sonnenberg III JL;Morgan Jl;Curran T
  35. The Essence of Oriental Medicine v.19 Ahn KS