Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Effects of Acori Graminei Rhizoma Aqua-acupunture Solution(AGRAS) on Induction of Cancer Chemopreventive Enzymes

석창포(石菖蒲) 약침액(藥鍼液)의 암(癌) 예방(豫防) 관련 효소 유도 효과

  • Roh Dong-Il (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongguk University) ;
  • Lim Jong-Kook (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongguk University)
  • 노동일 (동국대학교 한의과대학 경혈학교실) ;
  • 임종국 (동국대학교 한의과대학 경혈학교실)
  • Published : 2002.06.27
Download PDF
⟨ Previous Next ⟩

Abstract

Induction of phase II enzymes such as quinone reductase (QR) and glutathione S-transferase (GST) is considered a major mechanism of protection against initiation of carcinogenesis. The present study was performed to evaluate the chemopreventive activity of Acori Graminei Rhizoma aqua-acupuncture solution (AGRAS) and Acori Graminei Rhizoma water-extracted solution (AGRWS) by measuring the induction of phase II enzymes. AGRAS and AGRWS are potent inducers of quinone reductase activity in murine hepatoma Hepa1c1c7 cells. The levels of GSH and GST was increased sightly with AGRAS and AGRWS. These results suggest that AGRAS and AGRWS may act as blocking agents against carcinogenesis by induction of phase II enzymes.

발암물질을 무독화시키는 QR 생성 유도를 살펴보기 위하여 석창포 약침액 및 열수추출액을 생쥐의 간암세포인 Hepa1c1c7에 처리하여 측정한 결과, 석창포 약침액의 농도를 증가시킬수록 높은 QR 생성율을 보였으며, QR 활성 유도효과 보다는 낮았찌만 GSH와 GST 생성도 증가하였다.

Keywords

References

  1. 腫瘤的辨證施治 錢伯文
  2. 韓鍼灸學會誌 v.10 no.2 金銀花藥鍼液이 抗癌 및 癌豫防 效果에 미치는 影響 金重完;林鍾國
  3. 歷代中醫腫瘤論選粹 林紅生
  4. 大韓韓醫學會誌 v.14 no.2 消積白流散의 抗癌 免疫增强 效果 및 Cisplatin의 腎臟毒性抑制에 미치는 影響 趙鐘竟
  5. 經絡原論 南相千
  6. Cancer Res. v.54 Screening of potential chemopreventive agents using biochemical markers of carcinogenesis Sharma S;Jill DS;Kelloff GJ;Vernon ES.
  7. Lancet. v.342 Chemoprevention of cancer Sporn MB.
  8. Cancer Res. v.52 no.Sup. Inhibition of carcinogenesis by minor dietary constituents Wattenberg LW.
  9. Proc. Natl. Acad. Sci. Mutagenicity of quinones pathways of metabolic activation and detoxification Chesis PL;Levin DE;Smith MT;Ernster L;Ames BN.
  10. Adv. Cancer Res. v.29 The role of glutathione and glutathione-S-transferase in mercapturic acid biosynthesis Boyland E;Chasseud CF.
  11. 東醫寶鑑 許浚
  12. 한약약리학 김호철
  13. 中藥臨床應用大全 徐樹楠
  14. 抗痛治驗本草 陳敬章
  15. 中草藥主射劑 錢百炎
  16. 한국생약학회지 v.30 no.3 금은화 약침액의 암예방효과 김중완;최혜경;손윤희;임종국;남경수
  17. 생명과학학회지 v.9 no.6 감두약침액의 암예방효과 한상훈;조경희;최혜경;임종국;손윤희;이임태;남경수
  18. 대한경락경혈학회지 v.18 no.1 생약약침액에 의한 phase ll 효소 활성 유도 윤성묵;조경희;손윤희;남경수;임종국
  19. Anal. Biochem. v.150 Measurement of protein using bicinchornic acid Smith PK;Krohn Rl;Hermanson GT;Mallia AK;Gartner FH;Provenzano MD;Fujimoto EK;Goeke NM;Olson BJ;Klenk DC.