Korean Journal of Acupuncture

  • 제19권2호
  • /
  • Pages.57-61
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  • 2002
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  • 2287-3368(pISSN)
  • /
  • 2287-3376(eISSN)
경락경혈학회 (Society for Meridian and Acupoint)
권호 표지

생쥐에서 천궁(川芎) 약침액(藥鍼液)이 Cytochrome P450 효소 활성에 미치는 영향(影響)

Effects of Cnidium officinale Makino Aqua-acupunture Solution on the Activity of Cytochrome P450 Enzyme in Mice

  • 한상훈 (동국대학교 한의과대학 경혈학교실) ;
  • 손윤희 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터) ;
  • 남경수 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터) ;
  • 임종국 (동국대학교 한의과대학 경혈학교실)
  • Han Sang-Hun (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongguk University) ;
  • Shon Yun-Hee (Dept. of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University) ;
  • Nam Kyung-Soo (Dept. of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University) ;
  • Lim Jong-Kook (Dept. of Meridian & Acupoint, College of Oriental Medicine, Dongguk University)
  • 발행 : 2002.06.27
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초록

천궁약침액을 7일간 중완혈, 간수혈 및 임의혈에 투여한 후 마우스의 간에서 유도되는 phase I enzyme 억제 효과를 살펴본 결과 천궁 약침액은 CYP 1A1를 저해하였고, 생체의 CYP 2E1의 활성도 억제하였으므로 천궁 약침액은 암예방 효과가 있을 것으로 사료된다.

The activities of phase I enzymes in the liver of mice were examined following the intragastric application of Cnidium officinale Makino aqua-acupunture solution (COMAS). Treatment of mice with COMAS resulted in decreases of cytochrome P450 1A1-dependent ethoxyresorufin-O-deethylation and cytochrome P450 2E1-dependent p-nitrophenol and aniline hydroxylation activities. These findings suggest that COMAS has chemopreventive potential by inhibiting cytochrome P450 1A1 and cytochrome P450 2E1 activities in mice.

키워드

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