The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effects of Gamisachi-tang on the Serotonin Contents in Separate Brain Region of Mice Immobilized by Stress

가미사칠탕(加味四七湯)이 구속 Stress 생쥐의 뇌 부위별 Serotonin 함량에 미치는 영향

  • Jun, Chan-Yong (Department of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Park, Jong-Hyung (Department of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Han, Yang-Hi (Department of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Kim, Dong-U (Department of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Park, Se-Gi (Department of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Choi, You-Kyung (Department of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Baek, Eun-Gi (Department of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Han, Ji-Wan (Department of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Ha, Kyung-Sik (Department of Neurology, Gachon College of Medicine, Dong-Inchon Kil Hospital) ;
  • Hong, Ui-Sil (Department of Internal Medicine, College of Oriental Medicine, Kyung-won University)
  • 전찬용 (경원대학교 한의과대학 내과학교실) ;
  • 박종형 (경원대학교 한의과대학 내과학교실) ;
  • 한양희 (경원대학교 한의과대학 내과학교실) ;
  • 김동우 (경원대학교 한의과대학 내과학교실) ;
  • 박세기 (경원대학교 한의과대학 내과학교실) ;
  • 최유경 (경원대학교 한의과대학 내과학교실) ;
  • 백은기 (경원대학교 한의과대학 내과학교실) ;
  • 한지완 (경원대학교 한의과대학 내과학교실) ;
  • 하경식 (가천의대 동인천 길병원 신경과) ;
  • 홍의실 (경원대학교 한의과대학 내과학교실)
  • Published : 2002.03.30
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Abstract

Background and Objectives ; This experimental study was conducted to evaluate an anti-stress effect of Gamisachi-tang(加味四七湯) on mice immobilized by stress. Methods : The experimental animals were immobilized by stress for 15 minutes, and administered 9mg/20g or 18mg/20g of Gamisachi-tang(加味四七湯) extract for seven days before they got stressed. The serotonin contents in the frontal cortex, hypothalamus, corpus striatum, hippocampus were measured by HPLC method in rat brain. Results : In frontal cortex, serotonin contents significantly decreased in both sample A and B group compared to the controlled group. In the hypothalamus, serotonin contents increased in both sample A and B group compared to the controlled group. In the corpus striatum, serotonin contents significantly increased in both sample A and B group compared to the controlled group. In the hippocamous, serotonin contents significantly increased in both sample A and B group compared to the controlled group. Conclusions : According to the above results, Gamisachi-tang(加味四七湯) had a significant impact on the changes in serotonin contents, which occurred in a separated part of mouse brain caused by stress.

Keywords

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