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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Curcumin Suppresses Activation of NF-κB and AP-1 Induced by Phorbol Ester in Cultured Human Promyelocytic Leukemia Cells

  • Han, Seong-Su (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Keum, Young-Sam (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Seo, Hyo-Joung (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Surh, Young-Joon (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
  • Published : 2002.05.31
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Abstract

Many components that are derived from medicinal or dietary plants possess potential chemopreventive properties. Curcumin, a yellow coloring agent from turmeric (Curcuma longa Linn, Zingiberaceae), possesses strong antimutagenic and anticarcinogenic activities. In this study, we have found that curcumin inhibits the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear factor ${\kappa}B$ (NF-${\kappa}B$) activation by preventing the degradation of the inhibitory protein $I{\kappa}B{\alpha}$ and the subsequent translocation of the p65 subunit in cultured human promyelocytic leukemia (HL-60) cells. Alternatively, curcumin repressed the TPA-induced activation of NF-${\kappa}B$ through direct interruption of the binding of NF-${\kappa}B$ to its consensus DNA sequences. Likewise, the TPA-induced DNA binding of the activator protein-1 (AP-1) was inhibited by curcumin pretreatment.

Keywords

References

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