Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Adverse Effects of the Megadose Perilla Oil on the Rats Metabolism

들깨기름을 다량 투여한 흰쥐에서 대사에 미치는 역작용에 관하여

  • Published : 2002.04.01
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Abstract

In the present study, adverse effects of megadose of dietary perilla oil were investigated in an experimental model consisted of 6 groups of Wistar rats. To compare the adverse effects of megadose perilla oil with different kind of dietary fat, rats were fed one of the following diets for one month: 10% beef tallow (B$_1$B), 10% corn oil (C$_1$B), 10% perilla oil (P$_1$B), 20% beef tallow (B$_2$B), 20% corn oil (C$_2$B), and 20% perilla oil (P$_2$B) diet. The body weight gain rate seemed to be more affected by the size of fat contents than the species of fat in the diet, so the body weight gain rate of 20% fat groups were significantly higher than those of 10% fat groups in spite of the larger amount of flood intake in 10% fat groups than in 20% fat groups. The levers of plasma triglyceride and total-cholesterol in 20% fat groups were significantly increased in dose dependent fashion when compared to 10% groups, the values of beef tallow (B$_2$B) group being the highest among all groups. Plasma glutainic pyruvic transferase activities and level of blood urea nitrogen had a tendency to increase along with increase of fat contents (%) in diets, the values of P$_2$B group, the highest among all groups, being beyond the normal levers. The plasma carbon dioxide concentration of P$_2$B group was the highest in all groups and exceeded the normal value, there being no significant difference among the plasma carbon dioxide concentration of others groups. The results showed that large dose and long term intake of dietary perilla oil had some adverse effects on hepatic and other organic functions in rats.

횐쥐 사료에 10%와 20% 수준의 들깨기름, 옥수수기름, 소기름을 각각 배합하여 1개월간 사육한 결과를 비교하니 체중 증가율은 식이 유지 종류에 의한 영향보다도 식이내 유지 함량에 의해 영향을 더 크게 받아 20% 유지군들의 사료 섭취량이 10% 유지군보다 떨어졌음에도 불구하고 20% 유지군들이 10%유지군들보다 체중이 더 증가하였다. 혈중 중성지방량과 총 cholesterol량은 식이내 지방 함량 의존성으로 증가하여 20%유지군들이 10% 유지 군보다 증가하였고 그중에서 소기름군이 가장 높았다. GPT와 BUN값은 식이내 유지 함량 증가에 따라 측정값들이 증가하는 경향이고 20%들깨군의 측정값들은 모두 정상값의 범위를 초과하고 실험군들 중에서 가장 높았다. 혈중 $CO_2$농도는 실험군들 중에서 20% 들깨 기름군이 가장 높았고 정상값을 초과하였다. 나머지 실험군들은 $CO_2$농도 상호간 거의 차이가 없었다. 따라서 흰쥐를 들깨기름의 함량이 높은(20%)사료로 1개월간 사육하였을때 간장 및 기타 장기들의 기능에 약간의 역작용을 주는 것으로 보였다.

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