The Hepatoprotective Effects of Polysaccharides Isolated from Submerged Fermentation of Ganoderma lucidum

  • Zhang, Xue-Hong (College of Life Science and Biotechnology, Shanghai Jiaotong University) ;
  • Hu, Hong-Bo (College of Life Science and Biotechnology, Shanghai Jiaotong University) ;
  • Tang, Yong-Lian (College of Life Science and Biotechnology, Shanghai Jiaotong University) ;
  • Huang, Rui-Shan (College of Life Science and Biotechnology, Shanghai Jiaotong University) ;
  • Luo, Jiu-Fu (College of Life Science and Biotechnology, Shanghai Jiaotong University)
  • Published : 2002.06.01

Abstract

A neutral polysaccharide, GP, was isolated from a fermentation broth of Ganoderma lucidum Acid hydrolysis and a paper chromatography analysis indicated that the polysacchride was composed of glucose, xylose, and mannose. The molecular weight was estimated to be $2.9{\times}10^4$. The oral administration of GP to mice showed that it can inhibit liver damage induced by GalN and $CCl_4$.

Keywords

References

  1. Biochem. J. v.96 The gel-filtration behariour of proteins related to their molecular weighs over a wide range Andrews, P. https://doi.org/10.1042/bj0960595
  2. Anal. Cham. v.28 Colorimetric method for determination of sugers and related substances Dubois, M.;K.A. Gilles;J.K. Hamilton;P.A. Roberts;F. Smith https://doi.org/10.1021/ac60111a017
  3. J. Immunol. Immuno-pharmacol. v.11 Immuno-modulatory substance of fungal origin Jong, S. C.;J. M. Birmingham;S. H. Pai.
  4. Kor. J. Appl. Microbiol. Biotechnol. v.24 Fractionation and antitumor activity of the water soluble exopolysaccharide by submerged cultivation of Ganoderma lucidum mycelium Lee, S. Y.;T. S. Kang;S. O. Moon;I. D. Lew;M. Y. Lee
  5. Adv. Appl. Microbiol. v.37 Medicinal benefits of mushroom Ganoderma Jong, S. C.;J. M. Birmingham https://doi.org/10.1016/S0065-2164(08)70253-3
  6. Acta Microbiol. Sinica v.40 Purification and its biological activities of exo-polysaccharide of Ganoderma lucidum Li, P. Z.;K. Q. Zhang
  7. Pharm. Res. v.42 Effects of acetylbergenin against D-galactosamine-induced hepatotoxicity in rats Lim, H. K.;H. S. Kim;H. S. Choi;S. W. Oh;C. G. Jang https://doi.org/10.1006/phrs.2000.0730
  8. J. Fuzhou Univ. v.25 Studies on extraction and structure of the polysaccharide from Ganoderma lucidum strain GL 8801 by liquid fermentation Lin, Y. H.
  9. Analytical Lab. v.17 no.4 Analysis of the structure of polysaccharide from the fermentation broth of Ganoderma lucidum Luo, L. X.;S. Q. Zhou;R. H. Yao
  10. Food Reviews International v.11 Reishi, Ganoderma lucidum and Ganodermatsugae: Bioactive substances and medicinal effects Mizuno, T.;G. Wang;J. Zhang;H. Kawagishi;T. Nishitoba;J. Li https://doi.org/10.1080/87559129509541025
  11. Anal. Biochem. v.95 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Ohkawa, H.;N. Ohishi;K. Yagi https://doi.org/10.1016/0003-2697(79)90738-3
  12. Am. J. Clin. Pathol. v.28 A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases Reitman, S.;S. Frankel https://doi.org/10.1093/ajcp/28.1.56
  13. Agr. Biolog. Chem. v.49 Structure and antitumor activities of the polysaccharide isolated from fruiting body and the growing culture of mycelium of Ganoderma lucidum Sone, Y.;R. Okura;N. Wada;E. Kishida;A. Misaki https://doi.org/10.1271/bbb1961.49.2641
  14. J. Microbiol. Biotechnol. v.8 Hepatoprotective effect of extracellular polymer produced by submerged culture of GLWK-003 Song, H. C.;B. K. Yang;K. S. Ra;D. H. Shon;E. J. Park;G. I. Go;Y. H. Kim
  15. Biotanical Bull. Academia Sinica. v.25 Study on Ganoderma lucidum I. Liquid culture and chemical composition of mycelium Tseng, T. C.;M. S. Shiao;Y. S. Shieh;Y. Y. Hao
  16. Nat. Med. v.53 Effects of geraniin of the liver in rats Ⅲ - cirrelation berween lipid accumulation and liver damage in CCI₄-treated rats Yuka, N.;O. Takuo;A. Hiroko
  17. Process Biochem. v.33 The influence of environmental conditions on polysaccharide formation by Ganoderma lucidum in submerged cultures Yang, F. C.;C. B. Liau https://doi.org/10.1016/S0032-9592(98)00023-5