Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Inhibitory Effects of Ninety Nine Korean Plants on Human Immunodeficiency Virus Type 1 Pretense Activity

  • Park, Jong-Cheol (Department of Oriental Medicine Resources) ;
  • Hur, Jong-Moon (Department of Oriental Medicine Resources) ;
  • Park, Ju-Gwon (Department of Oriental Medicine Resources) ;
  • Hyun, Kyu-Hawn (Department of Resources Plants, Sunchon National University) ;
  • Lee, Kab-Yeon (Sobu Forest Experiment Station, Korea Forest Genetics Research Institute) ;
  • Hirotsugu Miyashiro (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University) ;
  • Masao Hattori (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University)
  • Published : 2002.06.01
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Abstract

Ninety nine extracts from Korean plants were screened for their inhibitory activities on human immunodeficiency virus (HIV) type 1 pretense by an HPLC method. The pretense inhibitory activities were determined by incubating the extracts in reaction mixtures containing pretense and substrate (His-Lys-Ala-Arg-Val-Leu-(p-NO$_2$- Phe)-Glu-Ala-Nle-Ser-NH$_2$) to perform proteolytic cleavage reactions. Of the extracts tested, the water extracts of Viburnum awabuki (stem and leaves) and Distylium racemosum (leaves) had the highest pretense inhibitory activities at a concentration of 100ug/mL. Activity-guided fractionation, revealed that the n-butanol fraction of the V. awabuki extract and the ethyl acetate fraction from the D. racemosum extract had the greatest inhibitory activity on HIV-1 pretense.

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References

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