Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Iron Supplementation on Mineral Utilization in Rats

철 보충이 흰쥐의 무기질 이용에 미치는 영향

  • Jun, Ye-Sook (Dept. of Human Nutrition and Food Science, Chungwoon University) ;
  • Choi, Mi-Kyeong (Dept. of Human Nutrition and Food Science, Chungwoon University) ;
  • Kim, Ae-Jung (Dept. of Food and Nutrition, Hyejeon College) ;
  • Kim, Mi-Hyun (Dept. of Food and Nutrition, Sookmyung Women's University) ;
  • Sung, Chung-Ja (Dept. of Food and Nutrition, Sookmyung Women's University)
  • 전예숙 (청운대학교 식품영양학과) ;
  • 최미경 (청운대학교 식품영양학과) ;
  • 김애정 (혜전대학 식품영양과) ;
  • 김미현 (숙명여자대학교 식품영양학과) ;
  • 승정자 (숙명여자대학교 식품영양학과)
  • Published : 2002.08.01
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Abstract

The purpose of this study was to investigate the effect of iron supplementation on utilizations of various minerals, Ca, Mg, Na, K, Fe, Cu, Zn. Intakes, serum levels, and excretions of these minerals were analyzed and compared in rats fed diet with 100, 200, 400% of iron requirement (Fe, 2Fe, 4Fe groups) for 6 weeks. The feed intake, body weight gain and feed efficiency ratio were not significantly different among the groups. Serum Fe of 2Fe group was significantly lower than other two groups, and serum Zn of 4Fe group was highest. Mineral intakes were not significantly different among three groups. With iron supplementation, urinary excretions of Ca, Fe, Cu, Zn were elevated, but fecal excretions of minerals were not significantly different. And the daily retentions of Na and Fe were significantly elevated, but apparent absorbabilities of minerals were not significantly different. In summary, according to iron supplementation, mineral absorbabilities were not different but urinary excretions of some minerals were increased. Therefore, it could be suggested that adequate iron intake and well-balanced diet are more desirable than nutrient supplementation for mineral balance.

본 연구에서는 철의 섭취수준이 증가함에 따라 다양한 무기질의 이용변화를 알아보기 위하여 흰쥐를 대상으로 적정수준, 적정수준의 2배와 4배의 철을 6주간 공급한 후 칼슘, 마그네슘, 나트륨, 칼륨, 철, 구리, 아연의 혈청 수준 및 섭취량과 배설량에 의한 평형상태를 비교, 분석하였으며, 그 결과를 요약하면 다음과 같다. 사료 섭취량, 체중 증가량 및 사료효율은 철 보충에 따른 유의한 차이가 없었다. 철 보충에 따른 혈청 철과 아연 함량은 각 군별 차이를 보여 철 함량은 2배 공급군이 유의하게 낮았고 아연 함량은 4배 공급군이 다른 두군에 비해 유의적으로 높았다(p<0.05, p<0.05). 철 보충에 따라 철 섭취량이 유의적으로 증가한 것(p<0.01)을 제외하고 그 밖의 무기질 섭취량은 유의한 차이가 없었다. 소변 중 무기질 배설량은 철 보충에 따라 칼슘, 나트륨, 철, 구리, 아연이 각 군별 유의한 차이를 보였다(p<0.01, p<0.01, p<0.001, p<0.05, p<0.01). 대변 중 무기질 배설량은 철 보충에 따른 유의한 차이가 없었다. 1일 무기질 보유량은 철 보충에 따라 나트륨과 철이 유의한 차이를 보여(p<0.05, p<0.01) 철 보충이 증가할수록 이들 무기질의 보유량이 높게 나타났다. 그러나 무기질 흡수율은 철 보충에 따라 유의한 차이가 없었다. 이상의 연구결과를 종합할 때 요구량의 2배와 4배의 철 보충에 따라 무기질의 겉보기 흡수율은 유의한 차이가 없었다. 그러나 칼슘, 철, 구리, 아연의 소변중 배설량은 철 보충에 따라 유의적으로 감소함으로써 장기적인 철 보충이 이루어진다면 이와 같은 무기질의 체내 보유량이 감소함에 따라 영양상태가 저하될 수 있을 것으로 보여진다. 이와 같은 결과는 다양한 무기질의 평형상태를 유지하기 위 해서는 무기질 보충제를 이용하는 것보다 균형 잡힌 영양섭취나 일상식사를 통해 적정한 섭취수준을 유지하는 것이 중요하다는 것을 제시해주며, 앞으로 이에 대한 영양지도와 지속적 인 연구가 요구된다.

Keywords

References

  1. Ministry of Health and Welfare. 1999. Report on 1998 National Health and Nutrition Survey. Korea. p 75.
  2. National Statistical Office. 1999. Yearbook of statistics. Korea.
  3. Lee SS, Kim MK, Lee EK. 1990. Nutrient supplement usage by the Korean adult in Seoul. Korean J Nutrition 23: 287-297.
  4. Kim SH. 1994. Patterns of vitamin/mineral supplements usage among the middle-aged in Korea. Korean J Nutrition 27: 236-252.
  5. Halliwell B, Gutteridge JMC. 1990. Role of free radicals and catalytic metal ions in human disease. Method in Enzymology 186: 1-85. https://doi.org/10.1016/0076-6879(90)86093-B
  6. Salonen JT, Nyyssonen K, Kopela H, Tuomilehto J, Seppanen R, Salonen R. 1992. High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men. Circulation 86: 803-811. https://doi.org/10.1161/01.CIR.86.3.803
  7. McCord JM. 1991. Is iron sufficiency a risk factor in ischemic heart disease? Circulation 83: 1112-1114. https://doi.org/10.1161/01.CIR.83.3.1112
  8. McLaren GD, Muir WA, Kellermeyer RW. 1983. Iron overload disorders-natural history, pathogenesis, diagnosis and therapy. CRC Crit Rev Clin Lab Sci 19: 205-266. https://doi.org/10.3109/10408368309165764
  9. Kurinji N, Kebanoff MA, Graubard BI. 1986. Dietary supplement and food intake in women of child-bearing age. J Am Diet Assoc 86: 1536-1540.
  10. O'Dell BL. 1989. Mineral interactions relevant to nutrient requirements. J Nutr 119: 1832-1838. https://doi.org/10.1093/jn/119.suppl_12.1832
  11. Gipp WF, Pond WC, Kallfelz FA, Tasker JB, van Campen DR, Krook L, Visek WJ. 1974. Effect of dietary copper, iron and ascorbic acid levels on hematology, blood and tissue copper, iron and zinc concentrations and $^{64}Cu$ and $^{59}Fe$ metabolism in young pigs. J Nutr 104: 532-541. https://doi.org/10.1093/jn/104.5.532
  12. Anderson HD, McDonough KB, Elvehjem CA. 1940. Relation of the dietary calcium-phosphorus ratio to iron assimilation. J Lab Clin Med 25: 464-474.
  13. Hallberg L, Brune M, Erlandsson M, Sandberg AS, Rossander-Hulten L. 1991. Calcium: effect of different amounts on nonhemeand heme-iron absorption in humans. Am J Clin Nutr 53: 112-119. https://doi.org/10.1093/ajcn/53.1.112
  14. American Institute of Nutrition. 1977. Report of the ad hoc committee on standard for nutritional studies. J Nutr 107: 1340-1348. https://doi.org/10.1093/jn/107.7.1340
  15. NRC Food and Nutrition Board. 1978. Nutrient requirements of laboratory animals. Nat Aca Sci, Washington DC. p 16-20.
  16. 임정남. 1986. 식품의 무기성분 분석. 식품과 영양 7: 42-46.
  17. SAS Institute Inc. 1988. Guide personal computers. Cary, North Carolina. p 60-62.
  18. Johnson MA, Hove SS. 1986. Development of anemia in copperdeficient rats fed high levels of dietary iron and sucrose. J Nutr 116: 1225-1238. https://doi.org/10.1093/jn/116.7.1225
  19. Jung HR, Kim MK. 1982. Effect of different levels of dietary protein and iron on the Fe, Cu and Zn metabolism in rats. Korean J Nutr 15: 258-267.
  20. Standish JF, Ammerman CB, Simpson CF, Neal FC, Palmer AZ. 1969. Influence of graded levels of dietary iron, as ferrous sulfate, on performance and tissue mineral composition of steers. J Anim Sci 29: 496-503. https://doi.org/10.2527/jas1969.293496x
  21. Hoekstra WG. 1964. Recent observations on mineral interrelationships. Fed Proc 23: 1068-1076.
  22. Cox DH, Harris DL. 1960. Effect of excess dietary zinc on iron and copper in the rats. J Nutr 70: 514-520. https://doi.org/10.1093/jn/70.4.514
  23. Van Campen DR. 1969. Copper interference with the intestinal absorption of zinc-65 by rats. J Nutr 97: 104-107. https://doi.org/10.1017/S0007114507205781
  24. Wu WH, Meydani M, Meydani SN, Burklund PM, Blumberg JB, Munro HN. 1990. Effect of dietary iron overload on lipid peroxidation, prostaglandin synthesis and lymphocyte proliferation in young and old rats. J Nutr 120: 280-289. https://doi.org/10.1093/jn/120.3.280
  25. Bafundo KW, Baker DH, Fitzgerald PR. 1984. The iron-zinc interrelationship in the chick as influenced by eimeria acerbulina infection. J Nutr 114: 1306-1312. https://doi.org/10.1093/jn/114.7.1306
  26. Yoon TH, Kim HS. 1994. Effect of dietary iron levels on trace elements in plasma and tissue of rats. Kor J Gerontol 4: 24-31.
  27. Smith CH, Bidlack WR. 1980. Interrelationship of dietary ascorbic acid and iron on the tissue distribution of ascorbic acid, iron and copper in female guinea pigs. J Nutr 110: 1398-1408. https://doi.org/10.1093/jn/110.7.1398
  28. Hamilton DL, Bellamy JEC, Valberg JD, Valberg LS. 1978. Zinc, cadmium and iron interaction during intestinal absorption in iron deficient mice. Can J Physiol Pharmacol 56: 384-388. https://doi.org/10.1139/y78-057
  29. Solomons NW, Jacobs RA. 1981. Studies on the bioavailability of zinc in humans: effects of heme and non heme iron on the absorption of zinc. Am J Clin Nutr 34: 475-482. https://doi.org/10.1093/ajcn/34.4.475
  30. Standish JF, Ammerman CB, Palmer AZ, Simpson CF. 1971. Influence of dietary iron and phosphorus on performance, tissue mineral composition and mineral absorption in steers. J Anim Sci 33: 171-178. https://doi.org/10.2527/jas1971.331171x
  31. Seely JR, Humphrey GB, Matter BJ. 1972. Copper deficiency in an infant fed and iron-fortified formula. New Engl J Med 286: 109-110.
  32. Hedges JD, Kornegay ET. 1973. Interrelationship of dietary copper and iron as measured by blood parameters, tissue stores and feedlot performance of swine. J Anim Sci 37: 1147-1154. https://doi.org/10.2527/jas1973.3751147x
  33. Sherman AR, Moran PE. 1984. Copper metabolism in irondeficient materal and neonatal rats. J Nutr 114: 298-306.
  34. Forth W. 1970. Absorption of iron and chemically related metals in vitro and in vivo: The specificity of iron binding system in the intestinal mucosa of the rat. In Trace element metabolism in animals. Mills, CF, ed. Edinburgh, Lovingston. p 298-310.

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