Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effects of Crude Saponin and Saponin-free Fraction of Korea Red Ginseng on the Skin and Cerebral Blood Flow in the Rats

백서의 피부 및 뇌혈류에 미치는 고려홍삼 사포닌 및 비사포닌의 영향

  • Kim, Shin-Hee (Department of Physiology, College of Medicine, Chungnam National University) ;
  • Kim, Cuk-Seong (Department of Physiology, College of Medicine, Chungnam National University) ;
  • Park, Jin-Bong (Department of Physiology, College of Medicine, Chungnam National University) ;
  • Han, Chan-Soo (Department of Physiology, College of Medicine, Chungnam National University) ;
  • Kim, Kwang-Jin (Department of Physiology, College of Medicine, Chungnam National University) ;
  • Kim, Shin-Hye (Department of Physiology, College of Medicine, Konyang University) ;
  • Kim, Se-Hoon (Department of Physiology, College of Medicine, Konyang University) ;
  • Nam, Ki-Yeul (Ginseng & Tobacco Research Institute) ;
  • Jeon, Byeong-Hwa (Department of Physiology, College of Medicine, Chungnam National University)
  • Published : 2002.09.01
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Abstract

To study the effect of Korea red ginseng (KCG) on the skin and cerebral blood flow, we evaluated the change of skin perfusion rate and cerebral perfusion rate after the intravenous, intraperitoneal, and oral administration of crude saponin (CS) and saponin-free fraction (SFF) of KRG in the rats. The change of skin perfusion rate and cerebral perfusion rate was measured laser doppler flowmetry. The intravenous injections of CS or SFF of KRG and intraperitoneal injection of SFF of KRG did not change the relative skin and cerebral blood flow in the rats. When the rats were treated by the intraperitoneal injection of CS of KRG, relative cerebral blood flow was significantly increased with a time-dependent manner, however, relative skin blood flow was not influenced by the them. Oral administration of CS of KRG slightly increased skin blood flow in the rats. Also, the change of cerebral blood flow by transient bilateral carotid arterial clamp in the CS-treated rats was significantly decreased, compared with control groups. From the above results, it was suggested that Korea red ginseng have a increasing property of cerebral blood flow in the rats.

본 연구에서는 혈류량의 변화를 실시간으로 측정할 수 있는 레이져 도플러 혈류량측정장치를 이용하여 피부혈류 및 뇌혈류량에 미치는 고려홍삼의 사포닌과 비사포닌의 효능을 연구하고자 고려홍삼의 정맥내 복강내 및 구강내로 주입하고 혈류의 변화를 관찰하여 다음과 같은 결론을 얻었다. 고려 홍삼의 사포닌 성분은 피부혈류량에는 영향을 주지 않으나 뇌혈류량을 증가시키는 효능이 있다. 고려 홍삼의 비사포닌 성분은 피부혈류량 및 뇌혈류량에 거의 영향을 주지 않았다. 고려홍삼사포닌에 의한 뇌혈류량의 증가는 복강내 및 경구로 투여할 경우는 관찰할 수 있으나 정맥내로 직접 투여할 경우는 관찰되지 않았다. 이상의 결과를 종합해 볼 때 고려홍삼의 사포닌 성분은 뇌혈류량을 증가시키는 혈류개선작용이 있는 것으로 사료된다.

Keywords

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