생명과학회지 (Journal of Life Science)

  • 제12권5호
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  • Pages.549-554
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  • 2002
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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포공영약침액의 발암과정 blocking agent로서의 활성

Taraxacum mongolieum Hand-Mass Aqua-acupuncture Solution as the Blocking Agent of Carcinogenesis

  • 손윤희 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터) ;
  • 김소연 (동국대학교 한의과대학 경혈학교실) ;
  • 임종국 (동국대학교 한의과대학 경혈학교실) ;
  • 남경수 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터)
  • 발행 : 2002.10.01
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초록

포공영약침액의 암억제 효과를 살펴보기 위하여 quinone reductase (QR) 생성유도를 생쥐의 간암세포인 Hepa Iclc7를 이용하여 측정한 결과, 포공영약침액을 처리한 Hepa Iclc7에서 QR생성이 유도되었다. 또한 포공영약침액은 phase II detoxification 효소인 glutathione S-transfer-ase (CST) 활성을 증가시키고 glutathione 생성도 증가시켰다 QR과 CST는 간세포에서 주로 생성되는 phase II효소로 발암물질에 의해 일어나는 돌연변이와 종양화 효과를 막아주고 발암물질을 무독화 시키는 것으로 알려져 있다. 따라서 본 실험에서 포공영약침액은 QR 효소 생성 유도, glutathione 함량 증가 및 CST 효소활성 증대등 phase II detoxification의 기작을 통한 발암과정의 blocking agent로서 효과가 있음을 알 수 있었다.

Taraxacunf mongofieum Hand-Mass aqua-acupuncture solution (TMAS) was prepared and investigated og, the effect on initiation of carcinogenesis. The following effe.Is as a blocking agent were measured. .(a) Indu.ction of quinone reductase, (b) Induction of glutathione S-transferase activity (c) Increase of reduced glutathione. TMAS was potent inducer of quinone reductase in Hepa Iclc7 murine hepatoma cells. Clutathione S-transferase activity was increased with TMAS. In addition glutathione levels were increased about 1.6-fold with TMAS in cultured murine hepatoma Hepa Iclc7 cells.

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참고문헌

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