Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Eucommia ulmoides olivon Ethanol Extract on Lipid Metabolism and Antioxidant Enzyme Activities of Rats Fed High Fat Diet

고지방 식이를 투여한 흰쥐의 지질대사와 항산화 효소 활성에 미치는 두충 에탄올 추출물의 영향

  • 남상명 (정인대학 호텔조리과) ;
  • 강일준 (한림대학교 식품영양학과) ;
  • 정차권 (한림대학교 식품영양학과) ;
  • 정명은 (한림대학교 식품영양학과) ;
  • 함승시 (강원대학교 식품생명공학부) ;
  • 오덕환 (강원대학교 식품생명공학부)
  • Published : 2002.10.01
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Abstract

To investigate the effects of Ewomia ulmoides olivon extract on the serum and hepatic lipid status and anti-oxidant enzyme activities, male Sprague Dawley (SD) rats were given high fat diets and Eucomia ulmoides olivon ethanol extracts for 6 weeks. Rats were divided into (our groups consisting the control (C), Eucomia ulmoides oliuon extract fed group (CE), high fat diet group (CL) and the extract and high fat fed group (CLE). Eucomia ulmoides oliuon ethanol extract lowered total cholesterol, but increased HDL-cholesterol and HDL-cholesterol/total cholesterol of the serum compared to the control. On the other hand, the ratio of HDL-cholesterol/total cho-lcsterol (HTR) was increased by 55% (p<0.05). High fat diet significantly increased serum cholesterol contents, but decreased HDL-cholesterol level and HTR (p<0.05). Atherogenic index (AI) of CL group was increased by almost four times of the control (p<0.05). Triglycerides (TG) and phospholipids were also increased by high fat diet. Eucomia ulmoides oliuon ethanol extract decreased the levels of TG (p<0.05) and phospholipids (p<0.05). Although liver antioxidant engyme activities including glutathione sulfur transferase (GST), superoxide dismutase (SOD) and catalase were decreased by high fat diet, those were stimulated by the administration of Eucommia ulmoides olivon ethanol extract.

두충 에탄을 추출물이 생체내 지질대사 및 항산화 효소계에 미치는 영향을 조사하였다. 정상식이에 두충 추출물을 투여(CE)한 결과 총콜레스테롤은 대조군(C)에 비해 감소하는 경향을 나타내었으며 HDL은 증가하였으나 통계적 유의 성은 없었다 동맥경화 지수 역시 두충 추출물 투여군(CE)이 대조군 (L)에 비해 감소를 나타내었으며 HTR은 55%의 증가를 보였다(p<0.05. 고지방식이(CL)를 투여한 결과 혈청 콜레스테롤 함량은 대조군(C)에 비해 유의성있게(p<0.05) 증가하였으나 HDL과 HTR은 크게 감소되어 통계적 유의성 (p<0.05)을 나타내었다. 고지방식이군(CL)의 동맥경화지수(AI)는 대조군(C)에 비해 3.6배의 증가를 보였다(p<0.05). 고지방식이에 두충 추출물(CLE)을 투여했을 때 콜레스테롤 함량과 동맥경화지 수는 고지방식이군(CL)에 비해 감소하는 경향을 보였다. 고지방식이군(CL)의 중성 지방 함량과 인지질 함량은 대조군(C)에 비해 증가하는 경향을 나타내었으며 두충 추출물 투여(CLE)로 중성 지방은 CL군에 비해 크게 감소되었으며 (p<0.05) 인지질 또한 감소하는 경향을 보였다 간 지질대사에서 두충 추출물 투여군(CE)의 총 지질과 콜레스테롤은 대조군(C)에 비해 다소 감소하는 경향이었고 인지질은 대조군보다 22% 증가하였다. 고지방식이 (CL) 투여 시간의 총지질, 콜레스테롤, HDL, 중성 지방은 대조군(C)에 비해 유의성있게(p<0.05) 증가하였다. 고지방식이 (CL)에 의해 GST활성은 유의 성 있게 감소하였으나 catalase와 SOD활성은 대조군(C)과 차이를 보이지 않았다. 두충 추출물의 투여에 의한 CE및 CLE군의 GST와cata-lase활성은 각각 C와 CL군에 비해 증가하는 경향을 보였다.

Keywords

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