Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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The Effect of Soy Isoflavone Supplementation on Urinary Isoflavone Excretion in Korean Postmenopausal Women

폐경 후 여성에서 이소플라본 공급에 따른 소변 중 이소플라본 배설량 변화에 관한 연구

  • 승정자 (숙명여자대학교 식품영양학과)
  • Published : 2002.12.01
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Abstract

It is well known that soy isoflavones play beneficial roles in the prevention of chronic diseases such as breast cancer, cardiovascular disease and osteoporosis. However current data are not sufficient for estimating the level of isoflavone intake. To use the urinary isoflavone excretion as a maker of isoflavone intake,26 participants consumed the isoflavone extract capsule (90 mg soy isoplavones/capsule) daily for 3 months. The study compared effects of pre- and post-isoflavone supplement in the following parameters; physical examination, dietary recalls, and urinary isoflavon excretion. The average age, height and weight were 65.7 years, 149.4 cm, and 57.3 kg. Subjects maintained regular diet pattern, and average daily nutrient intakes between pre- and post- supplementation were not significantly different except vitamin A, carotene and vitamin C. There was no significant difference between pre- and post- supplementation in terms of daily isoflavone intake. The basal urinary isoflavone excretion was 8.37 mg/day (daidzein 6.23 mu genistein 2.14 mg), and average daily excretion rate was IS.8%. Urinary isoflavone excretion was significantly increased, after isoflavone supplementation for 3 months as compared the basal level (p<0.01). Our data suggest that urinary isoflavone level, especially daidzein and genistein, may be a useful maker to estimate isoflavone intake.

이소플라본의 섭취량 측정방법에서 식품중 함량분석이 미비한 실정이기 때문에 식이섭취조사 이외에도 소변을 통한 분석방법의 이용 가능성을 알아보고자 실시되었다. 전북 익산시에 거주하는 폐경 후 여성을 대상으로 3개월간 이소플라본 90mg을 함유한 대두 이소플라본 추출물을 매일 1회씩 섭취하도록 하고, 실험전과 실험 후반 3일간의 식이섭취조사와 1일간의 24시간 소변을 수집하여 소변으로의 이소플라본 배설량을 측정 비교한 결과를 요약하면 다음과 같다. 연구대상자 25명의 평균 연령은 64.2세였으며, 신장은 149.6 cm이었고, 체중과 체질량지수는각각 58.1 kg,25.9kg/m$^2$이었다. 연구대상자의 실험 전 열량 섭취량은 1일 평균 1337.5 kcal였으며, 이소플라본 공급기간 중에도 유의적인 차이를 보이지 않았다. 단백질의 섭취량은 실험전 1일 평균 56.9g으로 양호한 수준을 나타내었고, 이소플라본 공급 중에도 유의적인 차이를 보이지 않았다. 이외에 비타민 A, 카로틴, 비타민 C를 제외한 지질, 당질, 비타민, 무기질의 섭취량에 있어서도 실험 전과 실험 기간중에 유의적인 차이를 보이지 않았다. 일상식이중 총 이소플라본의 섭취량은 25.3 mg이었으며, 이중 다이드제인이 11.8 mg, 제니스테인이 13.5 mg이었다. 이소플라본 공급 기 간(90 mg/day)중 일상 식이를 통한 이소플라본의 섭취량은 21.5 mg으로 실험전과 유의적인 차이를 보이지 않았다. 이소플라본 공급전의 24시간 소변중 이소플라본(다이드제인과 제니스테인의 합) 배설량은 8.4 mg이었으며, 이소플라본 섭취량의 15.8%가 비례적으로 소변을 통하여 배설되었다. 매일 90mg의 이소플라본을 공급(90 mg/day)한 3개월 후에는 13.9mg으로 공급전에 비하여 유의적인 증가를 나타내었다(p<0.01). 이상의 결과를 통하여 24시간 소변을 통한 이소플라본 배설량 특히 다이드제인과 제니스테인의 측정은 이소플라본의 섭취수준을 파악할 수 있는 자료로 활용 가능성이 있음을 확인할 수 있었다. 그러나 본 연구는 대상자가 수가 적고 실험기관 공급수준의 다양성이 없다는 제한점을 가지고 있기 때문에 좀더 많은 인원수를 대상으로 기간과 섭취수준을 달리하는 등의 지속적인 연구가 수행되어야 할 것으로 사료된다.

Keywords

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