Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Effect of picolinic acid on nitric oxide synthesis in murine macrophage

  • Kwon, Oh-Deog (College of Veterinary Medicine, Chonbuk National University) ;
  • Do, Jae-Cheul (Gyeongbuk Veterinary Service Laboratory) ;
  • Lee, Keun-Woo (College of Veterinary Medicine, Kyungpook National University)
  • Published : 2002.09.01
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Abstract

To determine the effect of picolinic acid on NOㆍ production, murine macrophages were incubated with either medium, various concentrations of picolinic acid, or IFN-${\gamma}$ plus picolinic acid for 48 hr. Picolinic acid does not induce NOㆍ production by itself, it acted synergistically with INF-${\gamma}$ for the induction of reactive nitrogen intermediate production in murine macrophages. Thymidine incorporation appeared to be reciprocally related to nitrite levels, suggesting that IFN-${\gamma}$ plus picolinic acid induced NOㆍ synthesis exerted antiproliferative effects.

Keywords

References

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