한국세라믹학회지 (Journal of the Korean Ceramic Society)

  • 제39권5호
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  • Pages.490-497
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  • 2002
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  • 1229-7801(pISSN)
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  • 2234-0491(eISSN)
한국세라믹학회 (The Korean Ceramic Society)
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CaO-SiO2-B2O3계 결정화 유리의 제조와 in-vitro법을 이용한 생체활성 평가

Preparation of CaO-SiO2-B2O3 Glass-ceramics and Evaluation of Bioactivity Using in-vitro Test

  • 류현승 (서울대학교 재료공학부) ;
  • 서준혁 (서울대학교 재료공학부) ;
  • 김환 (서울대학교 재료공학부) ;
  • 홍국선 (서울대학교 재료공학부) ;
  • 김득중 (성균관대학교 재료공학과) ;
  • 이재협 (서울대학교 의과대학 정형외과) ;
  • 이동호 (서울대학교 의과대학 정형외과) ;
  • 장봉순 (서울대학교 의과대학 정형외과) ;
  • 이춘기 (서울대학교 의과대학 정형외과)
  • Ryu, Hyun-Seung (School of Materials Science and Engineering, Seoul National University) ;
  • Seo, Jun-Hyuk (School of Materials Science and Engineering, Seoul National University) ;
  • Kim, Hwan (School of Materials Science and Engineering, Seoul National University) ;
  • Hong, Kug-Sun (School of Materials Science and Engineering, Seoul National University) ;
  • Kim, Deug-Joong (Department of Materials Engineering, Sungkyunkwan University) ;
  • Lee, Jae-Hyup (Department of Orthopedic surgery, Seoul National University) ;
  • Lee, Dong-Ho (Department of Orthopedic surgery, Seoul National University) ;
  • Chang, Bong-Soon (Department of Orthopedic surgery, Seoul National University) ;
  • Lee, Choon-Ki (Department of Orthopedic surgery, Seoul National University)
  • 발행 : 2002.01.01
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초록

$CaO-SiO_2-B_2O_3$계의 결정화유리의 소결 특성 및 기계적 특성, 생체활성을 알아보았다. 이 조성의 결정화유리는 750-830${\circ}$ 사이에서 소결 되었으며 치밀한 미세구조를 보였다. 이 결정화 유리는 단사정계 월라스토나이트(monoclinic wollastonite), 칼슘보레이트(Calcium borate, $CaB_2O_4$) 결정상과 보로실리케이트(borosilicate) 유리 기지상(matrix)의 3상으로 구성되었다. 기계적 강도는 지금까지 알려진 다른 생체활성 세라믹스보다 우수하였으며 특히 압축강도(2813 MPa), 파괴인성($3.12 MPa{\cdot}m^{1/2}$)이 높았다. 생체활성은 결정화유리 중 calcium borate와 보로실리케이트 유리의 양에 의존하였는데, 용해도가 높은 calcium borate는 의사체액(SBF)의 칼슘이온의 과포화도를 상승시키고 borosilicate 유리는 탄산아파타이트 핵생성에 필요한Si-OH기를 형성시켜 탄산아파타이트 층이 빨리 생성되기 때문으로 판단된다. 따라서 $CaB_2O_4$와 borosilicate 유리가 많을수록 결정화유리의 생체활성이 뛰어난 것으로 생각된다.

Sintering property, mechanical property and bioactivity of $CaO-SiO_2-B_2O_3$ glass-ceramics were investigated. This glass-ceramics was sintered at 750-830${\circ}$ and showed nearly pore-free microstructure. The glass-ceramics consisted of three phases, i.e. monclinic-wollastonite, calcium borate and borosilicate glass matrix. The mechanical strength was higher than that of other bioactive ceramics, especially compressive strength(2813 MPa) and fracture toughness($3.12 MPa{\cdot}m^{1/2}$). Bioactivity of the glass-ceramics depends on amount of $CaB_2O_4$ and borosilicate glass matrix. It might be likely that more soluble $CaB_2O_4$ raises supersaturation of Ca ion in SBF solution and borosilicate glass forms Si-OH group that presents nucleation site of hydroxycarbonate apatite(HCA) layer. So, glassceramics of more $CaB_2O_4$ and borosilicate glass showed better bioactivity.

키워드

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