Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on Study on Antitumor Activity of Kamisamchulsamja-tang

가미삼출삼자탕의 항암활성에 관한 연구

  • Kim Seong Eon (Oriental Medical College, Daejon University) ;
  • Lee Hyo Jeong (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim Dong Hee (Oriental Medical College, Daejon University) ;
  • Song Gyu Yong (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim Sung Hoon (Graduate School of East-West Medical Science, Kyunghee University)
  • 김성언 (대전대학교 한의과대학) ;
  • 이효정 (경희대학교 동서의학대학원) ;
  • 김동희 (대전대학교 한의과대학) ;
  • 송규용 (경희대학교 동서의학대학원) ;
  • 김성훈 (경희대학교 동서의학대학원)
  • Published : 2002.08.01
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Abstract

The purpose of this study was to investigate the effect of Kamisamchulsamja-tang (KSST) water extract on the antitumor activity. The results were summarized as follows: KSST extract exhibited a weak cytotoxicity against HT1080, A549, SK-OV-3, B16-F10 and SK-MEL-2 cells. KSST extract showed a inhibitoty effect on DNA topoisomerase I from calf thymus in a dose-dependent manner. Also, KSST extract showed antiadhesive effect on HT1080 cells but didn't showed on A549 cells to complex extracellular matrix. In pumonary colonization assay, a number of colonies in the lungs were decreased significantly in KSST treated group as compared with control group. In vitro neovascularization assays, angiogenesis was significantly inhibited in KSST treated group than control group. In CAM assay, KSST extract inhibited angiogenesis significantly at 15㎍/egg concentration as compared with control. From the above results it was concluded that KSST showed antitumor effect through the antimetastatic effect. So it is expected to be clinically helpful on the prevention of metastasis of cancer.

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