Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Effect of Buthus martensi Karsch Herbal-acupuncture on Immune Responses to Adjuvant Induced Arthritis in Rats

전갈약침이 adjuvant 유발 흰쥐의 관절활액막내 cytokine과 prostaglandin E2에 미치는 영향

  • Song, In-Kwang (Department of Acupuncture & Moxibustion, college of Oriental Medicine Dong-Guk University) ;
  • Choi, Woo-Shik (Department of Acupuncture & Moxibustion, college of Oriental Medicine Dong-Guk University) ;
  • Park, Joon-Sung (Department of Acupuncture & Moxibustion, college of Oriental Medicine Dong-Guk University) ;
  • Lee, Seung-Deok (Department of Acupuncture & Moxibustion, college of Oriental Medicine Dong-Guk University) ;
  • Kim, Kap-Sung (Department of Acupuncture & Moxibustion, college of Oriental Medicine Dong-Guk University)
  • 송인광 (동국대학교 한의과대학 침구학교실) ;
  • 최우식 (동국대학교 한의과대학 침구학교실) ;
  • 박준성 (동국대학교 한의과대학 침구학교실) ;
  • 이승덕 (동국대학교 한의과대학 침구학교실) ;
  • 김갑성 (동국대학교 한의과대학 침구학교실)
  • Received : 2002.03.01
  • Accepted : 2002.03.16
  • Published : 2002.04.20
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Abstract

Objective : The purpose of this study is to investigate the immunohistological effect of Buthus martensi Karsch Herbal-acupuncture in treating the arthritis, performed several experimental items : those are paw edema, $IL-1{\beta}$, IL-6, IL-8, $TNF-{\alpha}$ and $PGE_2$. Methods : All the male Sprague Dawley rats used in this study were bred and maintaned in our pathogen-free rat colony and were 8 weeks of age at the start of to experiment. The experimental model of arthritis was induced by injection of $50{\mu}g/{\mu}{\ell}$ adjuvant(mineral oil mixed Mycobacterium butyricum). Buthus martensi Karsch Herbal-acupuncture was injected into ST36(足三里) of rats daily for 21 days. Immunohistological analysis was carried out to assess paw edema, $IL-1{\beta}$, IL-6, IL-8, $TNF-{\alpha}$ and $PGE_2$ expression in synovial membrane and sera Buthus martensi Karsch Herbal-acupuncture injected. Results : Buthus martensi Karsch Herbal-acupuncture group showed a decrease with statistical significance, in paw edema, $IL-1{\beta}$, IL-6, IL-8, $TNF-{\alpha}$ and $PGE_2$ in synovial membrane and sera compared with control group. Conclusion : Buthus martensi Karsch Herbal-acupuncture stimulation inhibited the development of immunity to adjuvant induced arthritis in rats. Thus, Buthus martensi Karsch Herbal-acupuncture may have preventive effects on autoimmune inflammatory joint diseases as arthritis. The effect of Buthus martensi Karsch Herbal-acupuncture on the immune function and the disease activity in patients with arthritis warrants further investigation.

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