대한수의학회지 (Korean Journal of Veterinary Research)

  • 제42권3호
  • /
  • Pages.321-326
  • /
  • 2002
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  • 2466-1384(pISSN)
  • /
  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지

UV-light 에 의한 혈관 이완작용에 있어서 nitric oxide와 prostanoid의 관련성

Involvement of Nitric Oxide and Prostanoid on Photorelaxation in Pig Renal Artery

  • 김주헌 (경상대학교 수의과대학, 동물의학연구소) ;
  • 심철수 (경상대학교 수의과대학, 동물의학연구소) ;
  • 전석철 (마산삼성병원 심장센터)
  • Kim, Joo-Heon (College of Veterinary Medicine, Gyeongsang National University and Institute of Animal Medicine) ;
  • Shim, Cheol-Soo (College of Veterinary Medicine, Gyeongsang National University and Institute of Animal Medicine) ;
  • Jeon, Seok-Cheol (Cardiac center, Mason Samsung General Hospital Masan)
  • 심사 : 2002.08.29
  • 발행 : 2002.09.30
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초록

The effect of nitric oxide synthase(NOS) inhibita, $N^G$-nitro-L-arginine-methyl ester(L-NAME) and prostanoid synthesis inhibiter, indomethacin on the photorelaxation, when was exposed to the long-wave length UV-light, was examined on the precontraction by the phenylephrine in the isolated pig renal artery. 1. UV-light relaxed both with-endothelium and without-endothelium in the pig renal arterial ring contracted by the phenylephrine. The magnitude of photorelaxation was dependent on the exposure time for UV-light. 2. UV-Iight induced relaxation was inhibited by L-NAME and indomethacin on the precontraction by the phenylephrine in the isolated pig renal artery. 3. UV-Iight induced relaxation was inhibited by methylene blue on the precontraction by the phenylephrine in the isolated pig renal artery. These results suggest that UV-light induced photorelaxation may be due to cGMP involved both nitric oxide and prostanoid on the precontraction by the phenylephrine in the isolated pig renal artery.

키워드

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