Blood groups and antierythrocyte antibody for prevention of neonatal isoerythrolysis in horse

신생자마 용혈성 질환 예방을 위한 번식마의 혈액형과 항적혈구 항체 조사

  • Cho, Gil-Jae (Equine Blood Typing Laboratory, Korea Racing Association) ;
  • Yang, Young-Jin (Equine Blood Typing Laboratory, Korea Racing Association) ;
  • Cho, Byung-Wook (Department of Animal Science, Miryang National University) ;
  • Kim, Bong-Hwan (College of Veterinary Medicine, Kyungpook National University)
  • 조길재 (한국마사회 혈액형검사실) ;
  • 양영진 (한국마사회 혈액형검사실) ;
  • 조병욱 (밀양대학교 동물자원학과) ;
  • 김봉환 (경북대학교 수의과대학)
  • Accepted : 2002.12.04
  • Published : 2002.12.30

Abstract

This study was carried out to investigate the blood groups(Aa, Ca, Dc, Qa, Ua) and antierythrocyte antibody associated with neonatal isoerythrolysis(NI) in Thoroughbred horses. The blood groups from 1,351(35 stallions, 1,316 mares) Thoroughbred horses tested by serological procedures, and antierythrocyte antibody from 52 mares by indirect antiglobulin test. The blood groups(factor) of Aa, Ca, Dc, Qa and Ua positive were 97.1%, 100%, 91.4%, 82.9%, and 17.1% in stallions, respectively, and were negative 3.5%, 6.2%, 25.1%, 18.3%, and 77.1% in mares, respectively. These mares are considered to be at risk for production of an NI foals. The antierythrocyte antibody was not detected by this technique in all mares. These results suggest that the all breeding mares without blood groups Aa(3.5%) and Qa(18.3%) should be selected a appropriate stallion to prevent of neonatal isretythrolysis during the breeding season in Thoroughbred horses.

Keywords

References

  1. Witham CL, Carlson GO, Bowling AT. Neonatal isoerythrolysis in foals : management and prevention. California Veterinarian, 11:21-34, 1984
  2. Stormont C. Neonatal isoerythrolysis in domestic animals: A comparative review. Adv Vet Sci Comp Med, 19:23-45, 1975
  3. Cronin MTI. Haemolytic disease of newborn foals. Vet Rec, 67:479-494, 1955
  4. Nicholas FW. Introduction to Veterinary Genetics. Oxford University Press Inc, New York, 165-167, 1996
  5. Bowling AT. Horse genetics. CAB International, Wallingford, Oxon, UK, 82-96, 1996
  6. Bailey E, Albright DG, Hennet PJ. Equine neonatal isoerythrolysis: evidence for prevention by maternal antibodies to the Ca blood group antigen. American J Vet Res, 49:1218-1222, 1988
  7. McClure JJ. Strategies for prevention of neonatal isoerythrolysis in horses and mules. Equine Vet Educ, 9:118-122, 1997
  8. Stormont C, Suzuki Y, Rhode EA. Serology of horse blood groups. Cornell Vet, 54:439-452, 1964
  9. 岡田育穗. 動物의 免役分子遣傳學. 養賢堂, 東京, 77-78, 1995
  10. Scott AM. Principal red-cell antigens responsible for haemolytic disease of the newborn foal: Naturally occurring antibodies in Thoroughbreds. J Rayal Soc Med, 71:581-585, 1978
  11. Durham AE. Failure of the indirect and-globulin test to predict a case of neonatal isoerythrolysis. Equine Vet Educ, 9:115-117, 1997
  12. Scott AM, Jeffcott LB. Haemolytic disease of the newborn foal. Vet Rec, 103:71-74, 1978
  13. Becht JL. Neonatal isoerythrolysis in the foal. Part 1: Background, blood group antigens, and pathogenesis. Comp Cont Educ Pract Vet, 5:591-596, 1983
  14. Stormont C. Positive horse identification, Part 2, blood typing. Equine Pract, 1:48-54, 1979
  15. Zaruby JF, Heam P, Colling D. Neonatal isoerythrolysis in a foal, involving anti-Pa alloantibody. Equine vet J, 24:71-73, 1992
  16. Bailey E. Prevalence of anti-red blood cell antibodies in the serum and colostrum of mares and its relationship to neonatal isoerytholysis. Am J Vet Res, 43:1917-1921, 1982
  17. Cable CS. The Silent Stalker:Neonatal Isoerythrolysis. The Horse Interactive, February 1-6, 2001