The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Neuroprotective Effects of Uncariae Ramulus et Uncus on focal cerebral ischemia in rats brains

백서(白鼠)의 국부(局部) 뇌경색(腦硬塞)에 대한 조구등(釣鉤藤)의 신경보호(神經保護) 효과(效果)

  • Kwon Hyung-Su (Department of Circulatory Internal medicine, College of Oriental Medicine, Kyungsan University) ;
  • Oh Yong-Seong (Department of Circulatory Internal medicine, College of Oriental Medicine, Kyungsan University) ;
  • Lee So-Yeon (Department of Circulatory Internal medicine, College of Oriental Medicine, Kyungsan University) ;
  • Park Chi-Sang (Department of Circulatory Internal medicine, College of Oriental Medicine, Kyungsan University) ;
  • Park Chang-Gook (Department of Circulatory Internal medicine, College of Oriental Medicine, Kyungsan University) ;
  • Jang Woo-Seok (Department of Circulatory Internal medicine, College of Oriental Medicine, Kyungsan University)
  • 권형수 (경산대학교 한의과대학 심계내과학교실) ;
  • 오용성 (경산대학교 한의과대학 심계내과학교실) ;
  • 이소연 (경산대학교 한의과대학 심계내과학교실) ;
  • 박치상 (경산대학교 한의과대학 심계내과학교실) ;
  • 박창국 (경산대학교 한의과대학 심계내과학교실) ;
  • 장우석 (경산대학교 한의과대학 심계내과학교실)
  • Published : 2003.06.01
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Abstract

The goal of this study is to investigate whether Uncariae Ramulus et Uncus can protect nerve cells against ischemic neuronal damage is caused by middle cerebral artery occlusion (MCAO) in rats' brains and to investigate whether the neuroprotective effect of Uncariae Ramulus et Uncus is concerned with IEGs(immediate early genes) expression. Uncariae Ramulus et Uncus(l00mg/kg) was administered immediately after 2 hours of MCAO and maintained for 7 days. On 7th days after 2 hours of MCAO, the brains of rats were sliced through the hippocampus. c-Fos immunohistochemistry stain and Cresyl violet stain were done for microscopic examination. Each number of viable neurons and c-Fos immunoreactive cells in CA1 was counted. The density of neurons and c-Fos immunoreactive cells were significantly decreased in MCAO-operated ischemic rats compared to that sham-operated rats. Administration of Uncariae Ramulus et Uncus group significantly elevated MCAO-induced decrease in density of neurons, and elevated MCAO-induced decrease in c-Fos immunoreactive cells. These results suggest that the neuroprotective effect of Uncariae Ramulus et Uncus against focal cerebral ischemia. Also, we hypothesized that neuroprotective mechanism of Uncariae Ramulus et Uncus is related to IEGs expression.

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