The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Regulation of $[^3H]Norepinephrine$ Release by Opioids in Human Cerebral Cortex

  • Woo, Ran-Sook (Department of Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Shin, Byoung-Soo (Department of Neurology, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Kim, Chul-Jin (Department of Neurosurgery, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Shin, Min-Soo (Department of Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Jeong, Min-Suk (Department of Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Zhao, Rong-Jie (Department of Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School) ;
  • Kim, Kee-Won (Department of Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School)
  • Published : 2003.02.21
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Abstract

To investigate the receptors mediating the regulation of norepinephrine (NE) release in human cerebral cortex slices, we examined the effects of opioid agonists for ${\mu}$-, ${\delta}$-, and ${\kappa}$-receptors on the high potassium (15 mM)-evoked release of [$^3H$]NE. [$^3H$]NE release induced by high potassium was calcium-dependent and tetrodotoxin-sensitive. [$D-Pen^2$, $D-Pen^5$]enkephalin (DPDPE) and deltorphin II (Delt II) inhibited the stimulated release of norepinephrine in a dose-dependent manner. However, Tyr-D-Ala-Gly-(Me)Phe-Gly-ol and U69,593 did not influence the NE release. Inhibitory effect of DPDPE and Delt-II was antagonized by naloxone, naltrindole, 7-benzylidenaltrexone and naltriben. These results suggest that both ${\delta}_1$ and ${\delta}_2$ receptors are involved in regulation of NE release in human cerebral cortex.

Keywords

References

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