Antipyretic and Diuretic Activity of Ammania baccifera

  • Joanofarc, J. (Department of Pharmacognosy, Vels college of Pharmacy) ;
  • Sangeeta, J. (Department of Pharmacognosy, Vels college of Pharmacy) ;
  • Jayakumari, S. (Department of Pharmacognosy, Vels college of Pharmacy) ;
  • Kumar, S. Sadish (Department of Pharmaceutical Chemistry and Pharmacology, Vels College of Pharmacy) ;
  • Gopinadh, B. (Department of Pharmaceutical Chemistry and Pharmacology, Vels College of Pharmacy) ;
  • Sam, S. Kishore Gnana (Department of Phytopharmacy and Phytomedicine, JSS College of Pharmacy)
  • Published : 2003.09.01

Abstract

In the present study the whole plant of Ammania baccifera Linn was extracted with petroleum ether, chloroform, ethyl acetate and ethanol. The extracts were vacuum dried to yield the respective petroleum ether (PEE), chloroform (CE), ethyl acetate (EAE) and ethanol extracts (EE). PEE, CE, EAE and EE were evaluated for their antipyretic and diuretic activity at 200 mg/kg dose level. Significant antipyretic activity was associated with PEE, CE, EAE and EE. CE was found to exhibit higher antipyretic activity as paracetamol at 100 mg/kg dose level. Significant diuretic activity was exhibited by EAE, EE and PEE. The present study supports the claims of Ammania baccifera mentioned in the Indian system of medicine.

Keywords

References

  1. Anonymous., The Wealth of India Raw materials, CSIR New Delhi, India, pp. 68 (1948)
  2. Anonymous., The Wealth of India. Publications and Information Directorate, CSIR. New Delhi, India, pp. 224 (1985)
  3. Ambasta, S. P., CSIR,New Delhi, India. pp. 35, (1986)
  4. Anbalagan, N., Ranjinikanth,K N., Kishore Gnana Sam, S., and Sridhar, S. K, Analgesic, anti inflammatory and diureticactivity of Pissonia grandis, Natural Product Science. 8, 97 (1980)
  5. Goodman and Gilman, The Pharmacological Basis of Therapeutics, McGraw-Hill Companies. 9th Edition, pp. 607, 620 (1996)
  6. Kirthikar, K. R and Basu,B. D., Indian Medicinal plants. Publication and Information Division, CSIR, New Delhi, India. pp. 1071(1975)
  7. Pulok, K M., Das, J., Kakali, S., Giri, S. N., Pal, M., Saha, B. P., Antipyretic activity of Nelumbo nucifera rhizome extract, Indian journal ofExperimental Biology. 34, 275, (1996)
  8. Pulok, K. M., Quality Control ofHerbal Drugs, BusinessHorizons, New Delhi, India. pp. 398 (2002)
  9. Spiegel,M. R. and Meddis,R., Probability and Statistics. McGraw-Hill Book company, New York. pp. 108-151 (1980)
  10. Thakkar S. M, Deshmukh V. K, Saoji A.N., Duragkar N. J., J. Indian.chem. soc., 63(6), 619 (1986)
  11. Tripathi, K. D., Essentials ofMedical Pharmacology, JaypeeBrothers, New Delhi, India, 4th Edition, pp. 216 and 220 (2001)
  12. Turner, R. A. Diuretic and Natriuretic agents. Screening methods in Pharmacology, Academicpress Inc, London.pp. 251, (1965)
  13. Varierss, P. S., Indian medicinal plants a compendium of500 species, Orient Longman Ltd, Chennai, India. pp. 125 (1998)