Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Hepatoprotective Effects of Water Extract of Liriopis Tuber on Carbon Tetrachloride-Induced Hepatotoxicity in Rats

맥문동 열수추출물의 사염화탄소로 유발된 흰쥐의 간 손상에 대한 보호효과

  • An, Ji-Yoon (College of Pharmacy, Catholic University of Daegu) ;
  • Rhee, In-Ja (College of Pharmacy, Catholic University of Daegu)
  • 안지윤 (대구가톨릭대학교 약학대학) ;
  • 이인자 (대구가톨릭대학교 약학대학)
  • Published : 2003.06.30
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Abstract

The hepatoprotective effects of Liriopis tuber on carbon tetrachloride $(CCl_4)$ intoxicated rats were studied. The water extract prepared from Liriopis tuber were administrated to the pretreatment group orally once a day for successive 7 days, followed by treatment with $CCl_4$ on the seventh day. The post treatment group was treated with $CCl_4$ and then the water extract was administrated. The activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LDH), and contents of total cholesterol and triglyceride in pretreatment rats serum were significantly decreased compared to the only $CCl_4$ treated rats. The level of high density lipoprotein (HDL) cholesterol was considerably increased compared to the only $CCl_4$ treated rats. In the pretreatment group with the water extract of Liriopis tuber tissue destruction was not observed in light microscopic investigation, compared to the only $CCl_4$ treated rats. These results suggest that Liriopis tuber have potent hepatoprotective effect against carbon tetrachloride intoxicated rats.

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References

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