Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Some pharmacological studies with Cycleanine, a diphenylbisbenzylisoquinoline alkaloid from Stephania hernandifolia

  • Published : 2003.09.30
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Abstract

Stephania hernandifolia belonging to the family Menispermaceae is the biggest storehouse of diphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the bulb of S. hernandifolia by the application of modern separation techniques yielded a DBBI alkaloid which was identified as cycleanine using spectroscopic methods (UV, IR, $^1HNMR$. $^{13}CNMR$, Mass). Cycleanine showed significant anti-inflammatory activity against carrageenin induced paw oedema, comparable to that produced by diclofenac sodium, used as standard drug. It exhibited potent analgesic effects against chemical and thermal noxious stimuli. It was also found to possess anticonvulsive activity in the strychnine induced convulsion model.

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References

  1. Awe SO, Olajide OA, Adeboye JO, Makinde JM. (1998) Some pharmacological studies on Morinda lucida. Ind. J. Pharmacol. 30, 38-42.
  2. Bairy KL, Rao CM, Ramesh KV, Kulkarni DR. (1991) Effect of anti-histamines on wound healing. Ind. J. Expt. BioI. 29, 398-399.
  3. Banerjee S, Sur TK, Mandal S, Das PC, Sikdar S. (2000) Assessment of the anti-inflammatory effects of Swertia chirata in acute and chronic experimental models in male albino rats. Ind. J. Pharmacol. 32, 21-24.
  4. Bartolinin AM, Galli A, Ghelardin C, Gioti A, Malcangio M, Malmberg-Aiella P, Zucchi PL. (1987) Antinociception induced by systemic administration of local anaesthetics depends on certain cholinergic mechanism. Br. J. Pharmacol. 92, 711-721. https://doi.org/10.1111/j.1476-5381.1987.tb11375.x
  5. Chattpadhyay RN, Chattopadhyay RR, Roy S, Maitra SK. (1986) A simple method for plethysmometric measurement of paw volume of small laboratory animals in the evaluation of anti-inflammatory effects. Bull. Cal. Sch. Trap. Med. 29, 398-399.
  6. Chen G, Portman R. (1952) Titration of central nervous system depression. AMA Arch. Neural. Psychiat. 68, 499-505.
  7. Killan DF, Dasgupta SR, Willium EK. (1960) Inhibition in the nervous systemand gamma amino butyric acid, pp. 302, Edited by Eugen R, Pergamon press, Oxford.
  8. Kirtikar KR, Basu BD. (1984) Indian Medicinal Plants, Bishen Singh Mahendra Pal Singh, Dehradun, India, p. 32.
  9. Koster R, Anderson M, De Beer E J. (1959) Acetic acid for analgesic screening. Fed. Proc. 18, 412.
  10. Litchifield JT (Jr.), Wilcoxon F. (1949) A simplified method of evaluating dose-effect experiments. J. Pharm. Exp. Ther. 96, 99-113.
  11. Palanichamy S, Nagarajan S. (1990) Analgesic activity of Cassia alata leaf extract kaempferol-3-O-sophoroside. J. Ethnopharmacol. 29, 73-78. https://doi.org/10.1016/0378-8741(90)90099-F
  12. Ramanjaneyulu R, Ticku MK. (1984) Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore. Eur. J. Pharmacol. 987, 337.
  13. Seal Tapan, Mukherjee B. (1997) Pharmacological activities of bisbenzylisoquinoline alkaloids: a review. Journal of Medicinal and Aromatic Plant Sciences (CSIR). 19, 32-92.
  14. Sutinski IA, Priyatkina TN. (1964) Effect of certain drugs on gamma amino butyric acid content of central nervous system. Fed. Proc. 23, 879.
  15. Turner RA. (1965) Screening Method in Pharmacology, Vol. 1, A.P., New York and London, 114.
  16. Winter CA, Risely EA. Nuss GW. (1962) Carrageenin-induced oedema in hind paw of the rats-an assay for anti-inflammatory drugs. Proc. Soc. Exp. BioI. Med. 3, 544-547.