Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Anti-ulcer and wound healing activity of Ruta graveolens

  • Somchit, Nhareet (Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences) ;
  • Rahman, Shamima A. (Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences) ;
  • Ahmad, Zuraini (Pharmacology and Toxicology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences) ;
  • Abdullah, Abdul Salam (Faculty of Veterinary Medicine, University Putra Malaysia)
  • Published : 2003.09.30
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Abstract

The effects of ethanol extract of Ruta graveolens on ulceration induced by ethanol and wound healing properties were investigated in mice. Oral administration of the extract reduced the incidence of ulcer, ulcer index and ulcer length produced by ethanol. The gastroprotective effects of R. graveolens were observed in a dose-dependent manner. However, this activity was statistically less potent than the anti-ulcer drug, omeprazole. When the extract applied on the wound, it promoted wound healing in mice. The wound contraction was faster in these mice when compared to untreated wounds. Based on these present findings, R. graveolens possesses anti-ulcer activity and promotes incision wound healing in mice.

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References

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