Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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A Study on Antimutagenic Acitivities of the Extracts from Dianthi Herba

구맥(瞿麥)의 항돌연변이(抗突然變異) 활성(活性)에 관한 연구(硏究)

  • Seo Un-Kyo (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong Ji-Cheon (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 서운교 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실)
  • Published : 2003.12.30
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Abstract

Antigenotoxicity test (SOS chromotest) and antimutagenecity test (Ames test) were carried out using water-soluble and methanolic extracts from Dianthi Herba. Antigenotoxic activity of methanolic extract against mutagens both MNNG and NQO was much more effective than that of water-soluble one. When the extract was added to the certain concentration $(100\;{\mu}l/tube)$, antigenotoxic activities against both mutagens were enhanced. Against the mutagen MNNG with Ames test, antimutagenic activity of the methanolic extract was better than that of water-soluble one. The 74.6% of inhibition ratio for revertant forming CFU/plate was shown at $300\;{\mu}l/plate$ of the methanolic extract.

Keywords

References

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