Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Effect of Molokhia (Corchorus olitorius) and Its Mucilage on Cholesterol Metabolism in High Cholesterol Fed Rats

몰로키아가 고 콜레스테롤 식이를 투여한 흰쥐에서의 콜레스테롤 대사에 미치는 영향

  • Published : 2003.06.01
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Abstract

Effects of molokhia (Corchorus olitorius) and its mucilage on in vitro bile acid adsorption capacity and lipid composition using cholesterol-fed SD rats were investigated. Mucilage showed stronger affinity toward bile acid than hot water extract of molokhia powder. As the extracting temperature increased from 50 to $80^{\circ}C$, bile acid binding capacity of mucilage also increased from 41 to 83%. When molokhia powder or its mucilage added into cholesterol diet at 5 or 10% levels (as fiber source) was compared with cellulose-added group, total cholesterol and triglyceride levels of plasma showed no significant differences, whereas, HDL-cholesterol level of cellulose group significantly increased. Accumulation of cholesterol and triglyceride in liver were significantly inhibited in molokhia and mucilage groups. Molokhia and mucilage lowered the liver weights significantly. As the concentration of molokhia or mucilage increased, cholesterol and triglyceride levels in the liver was lowered. Cholesterol and triglyceride excreted through feces were significant increased in molokhia- or mucilage-fed group, with excretion of cholesterol by molokhia-fed group being mere distinct.

국내산 몰로키아와 몰로키아 점질추출물인 mucilage가 콜레스테롤 대사에 미치는 효과를 담즙산 흡착능과 콜레스테롤 식이를 투여한 동물실험을 통하여 살펴보았다. In vitro에서 mucilage는 몰로키아 열수추출물에 비해 더 높은 담즙산 흡착능을 나타내었으며, 추출 온도가 높아짐에 따라 흡착능은 증가하는 경향을 보였다. 고 콜레스테롤 식이에 몰로키아 분말과 mucilage를 첨가한 경우 혈장의 총 콜레스테롤 함량은 대조구인 셀룰로오스 첨가군과 유의적인 차이가 나타나지 않았고, triglyceride 함량은 몰로키아 첨가군에서 증가되었으나 HDL-콜레스테롤인 경우는 몰로키아 분말과 mucilage 첨가군에서 유의적으로 증가하였다. 간이 몸무게에 대해 차지하는 비율을 측정해 본 결과, 셀룰로오스 첨가군은 $4.01{\sim}4.31%$이었으나 몰로키아 분말 섭취군에서는 $3.74{\sim}3.84%$, mucilage 첨가군에서는 $3.40{\sim}3.45%$의 낮은 값을 보여 몰로키아의 섭취로 간의 지질 침착이 어느 정도 억제될 수 있음을 나타내었다. 간에서의 중성 지방 농도는 셀룰로오스 군에 비해서 몰로키아 분말과 mucilage 첨가군이, 콜레스테롤 함량은 몰로키아 10% 첨가군에서, triglyceride는 mucilage 10% 첨가군에서 유의적으로 감소되었다. 변으로의 콜레스테롤 배설량은 몰로키아 분말 첨가군이 가장 높았고 mucilage 첨가군도 셀룰로오스군 보다 유의적으로 높았으며 triglyceride는 5% 수준에서는 mucilage 첨가 군이 매우 높았으나 10% 첨가시에는 처리구 간의 유의적인 차이는 보이지 않았다.

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