Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Radiosensitizing and Antitumor Effect of the Seed of Benincasae hispida

동과자(冬瓜子)의 항암활성과 방사선에 대한 감작효과

  • 최혜란 (건국대학교 동물자원연구센터) ;
  • 이경호 (코오롱중앙연구센터) ;
  • 김창한 (건국대학교 동물자원연구센터)
  • Published : 2003.06.01
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Abstract

Radiosensitizing and antitumor effects of hot water extract derived from the seed of Benincasae hispida were investigated. The extract showed maximum survival rate of 21% at 0.1 g/kg against L1210 cells implanted in BDF1 mice. Radiosensitivity of human tumor cell line was evaluated through sulforhodamine assay. Inhibition rate of SK-OV-3 cells after 5 Gy radiation by Benincasae hispida seed extract at 2 mg/mL was 86%.

동과자 열수 추출물의 in vitro 항암효과는 2 mg/mL의 농도에서 가장 높게 나타났으며 in vivo 상에서의 0.1 g/kg, 0.01 g/kg의 경구 투여시 각각 21%, 17%의 생명연장율(increased life span, ILS)을 나타내었다. SK-OV-3에 대한 SRB assay를 이용한 열수 추출물(2 mg/mL)의 방사선(5 Gy) 병용 투여에 있어서 86%의 저해효과를 나타내었다.

Keywords

References

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