한국식품과학회지 (Korean Journal of Food Science and Technology)

한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

가시오가피가 함유된 성장촉진용 조성물의 골성장효과 연구

A Study on the Longitudinal Bone Growth of Growth-stimulating Material with Eleutherococcus senticosus

  • 발행 : 2003.08.01
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초록

본 연구는 가시오가피를 함유한 성장촉진용 조성물인 GSM의 성장촉진 효과를 관찰하기 위하여, 족경골 말단의 성장판 증식과 골성장인자 IGF-1 유전자 발현에 미치는 영향, 골세포와 간세포에서 골성장인자 IGF-1 유전자 발현, 그리고 족경골의 생육 효과를 관찰하였다. GSM은 세포실험을 통하여 주요 성장 인자인 IGF-1을 간에서 합성을 촉진시킬 뿐만 아니라, 골에서도 합성을 촉진시키는 효과를 나타내었다. 그리고 간과 골에서 합성이 촉진된 IGF-1은 동물실험을 통하여 장골 길이 성장의 중요한 척도가 되는 성장판 말단부의 증식층 및 비대층의 연골세포 활력을 증대시켜 성장판 두께를 증가시켰고, 또한 골무기질밀도를 증가시키는 효과를 보여주었다. 따라서 본 연구는 GSM의 지속적인 연구를 통하여 성장기 어린이에게 성장촉진 및 골강화에 응용할 수 있는 소재로 개발 가능성이 있음을 제시하였다.

This study was conducted to evaluate the effect of a growth-stimulating material (GSM) containing Eleutherococcus senticosuson on the longitudinal bone growth. The effects of GSM on proliferation zone and IGF-1 mRNA expression in rat growth plate, IGF-1 mRNA expression in MG-63 osteoblast and Hep-G2 hepatocyte, and bone growth of mouse tibia were studied. GSM significantly increased the proliferation zone in growth plate of proximal tibia (P<0.001) and the IGF-1 mRNA expression in growth plate was also increased (P<0.01). Treatment of GSM to MG-63 osteoblast and Hep-G2 hepatocyte also increased IGF-1 mRNA expression more than twice. In addition, bone mineral density of mouse tibia was significantly increased by GSM (P<0.05). Therefore, it was shown that GSM has an activity of bone growth promotion by increasing the expression of IGF-1, a major bone growth factor.

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