Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effects of Acanthopanax senticosus herb-acupuncture on cell proliferation and nitric oxide synthase expression in dentate gyrus of alcohol-intoxicated rats

오가피(五加皮) 약침(藥針)이 알코올 중독(中毒) 흰쥐의 치상회(齒狀回)에서 신경세포생성(神經細胞生成) 및 NOS 발현(發顯)에 미치는 영향(影響)

  • Kim Jong-Chul (Dept. of Meridian & Acupoint, College of Oriental Medicine, Semyung University) ;
  • Lee Eun-Yong (Dept. of Acupuncture and Moxibustion, College of Oriental Medicine, Semyung University) ;
  • Kim Ho-Hyun (Dept. of Physiology, College of Oriental Medicine, Semyung University) ;
  • Kim Ee-Hwa (Dept. of Meridian & Acupoint, College of Oriental Medicine, Semyung University)
  • 김종철 (세명대학교 한의과대학 경혈학교실) ;
  • 이은용 (세명대학교 한의과대학 침구학교실) ;
  • 김호현 (세명대학교 한의과대학 생리학교실) ;
  • 김이화 (세명대학교 한의과대학 경혈학교실)
  • Published : 2003.06.27
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Abstract

목적 : 오가피 약침이 알코올에 의해서 중독된 Sprague-Dawley(S-D)계 흰쥐의 해마 치상회에서 새로운 신경세포 생성 및 NOS발현에 미치는 영향을 조사하였다. 방법 : S-D계 흰쥐에 알코올을(2g/kg) 3일간 연속으로 투여한후, 5일간 인체의 중완혈에 상응하는 부위에 오가피 약침(30mg/kg) 치료를 시행하였다. 치료효과를 관찰하기 위해서 BrdU-면역조직화학 염색법 및 NADPH-d-조직화학염색법을 이용하였다. 결과 : 알코올 처치군에서는 BrdU-양성세포수 및 NADPH-양성세포수가 모두 정상군에 비해서 감소한 반면에 알코올 처치후 오가피 약침으로 치료한 군에서는 BrdU-양성세포수 및 NADPH-양성세포수 모두 알코올 처치군에 비해서 증가하였다. 결론 : 오가피 약침치료가 알코올에 의해서 중독된 S-D계 흰쥐 해마 치상회에서 새로운 신경세포의 생성을 증가시키는 것을 확인하였으며, 그 기전으로 산화질소가 관여할 것으로 사려된다.

Keywords

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