Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Effects of Folium Artemisiae Argyi and Moxa Tar' Herbal Acupuncture on Transient Forebrain Ischemic Injury in Rats

애엽(艾葉) 및 구진(灸津) 약침(藥鍼)이 일과성(一過性) 전뇌(前腦) 허혈(虛血) 손상(損傷)에 미치는 효과(效果)

  • Kim Jae-Hyo (Dept. of Meridian and Acupoint, College of Oriental Medicine, WonKwang University) ;
  • Lee Kwan-Hyung (Dept. of Meridian and Acupoint, College of Oriental Medicine, WonKwang University) ;
  • An Young-Nam (Dept. of Meridian and Acupoint, College of Oriental Medicine, WonKwang University) ;
  • Kim Yong-Deuk (Dept. of Meridian and Acupoint, College of Oriental Medicine, WonKwang University) ;
  • Kim Kyung-Sik (Dept. of Meridian and Acupoint, College of Oriental Medicine, WonKwang University) ;
  • Sohn In-Chul (Dept. of Meridian and Acupoint, College of Oriental Medicine, WonKwang University)
  • 김재효 (원광대학교 한의과대학 경혈학교실) ;
  • 이관형 (원광대학교 한의과대학 경혈학교실) ;
  • 안영남 (원광대학교 한의과대학 경혈학교실) ;
  • 김용득 (원광대학교 한의과대학 경혈학교실) ;
  • 김경식 (원광대학교 한의과대학 경혈학교실) ;
  • 손인철 (원광대학교 한의과대학 경혈학교실)
  • Published : 2003.09.27
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Abstract

Objectives : Acupuncture and herbal medicine have been used to prevent and treat the cerebrovascular accident, such as a stroke, and many studies of acupuncture and moxibustion concerning to the stroke have been undertaken in the human and various animals. Recently, the new therapeutic tool, that is herbal acupuncture, has been developed since the 1950' and applied to various diseases including the cerebrovascular accident. The main characteristics of herbal acupuncture are a combination of acupuncture and herbal medicine. It was not well known the therapeutic effect and the mechanism of herbal acupuncture on transient forebrain ischemic injury, although it has been used frequently in clinics. Methods : In this study, effects of folium Artemisiae Argyi and moxa tar' herbal acupuncture on the $GV_{20}$, named Baek-Hue, on neuroprotection after the transient forebrain ischemia were investigated in Sprague-Dawely rats. Expressions of cFos, FosB and BDNF protein in the hippocampus and cortex were observed at 2 hrs and 48 hrs after transient forebrain ischemia by immunohis- tochemistry and ELISA technique. Results : Expression of cFos protein was increased slightly in the hippocampus and cortex at 2 hrs after transient forebrain ischemia, but FosB protein was increased highly comparing to cFos protein. However, pretreatment with folium Artemisiae Argyi or moxa tar' herbal acupuncture on $GV_{20}$ significantly increased expression of cFos protein and significantly decreased expression of FosB protein compared to control group, respectively. These features were observed in the motor cortex and retrosplenial granular cortex as well as the hippocampus. Also, pretreatment with folium Artemisiae Argyi and moxa tar' herbal acupuncture on$GV_{20}$ significantly increased the expression of BDNF protein in the hippocampus and the cortex compared to control group at 48 hrs after transient forebrain ischemia, respectively. Conclusions : These results suggest that pretreatment with folium Artemisiae Argyi or moxa tar' herbal acupuncture on $GV_{20}$ has neuroprotective effect on transient forebrain ischemia and theherbal acupuncture on $GV_{20}$ may be related to antioxidative function.

Keywords

References

  1. 實用中風防治手冊 常靑
  2. 임상중풍학 김영석
  3. Neuroscience v.93 Hippocampal cell loss in transient global cerebral ischemia in rat ; A critical assessment Hergruido MJ;Carceller F;Roda JM;Avendano C
  4. J Neurol Sci v.179 Brain ischemia and reperfusion: molecular mechanisms of neuronal injury White BC;Sullivan JM;DeGracia DJ;O''Neil BJ;Neumar RW;Grossman Ll;Rafols JA;Krause GS
  5. 약침학 개론 및 임상 이혜정
  6. 本草學 全國韓醫科大學 本草學致室(共編著)
  7. J Korean Soc Food Nutr v.23 no.1 한국산 식용식물의 화학성분 및 생리활성(VI)-참죽나무 잎, 미나리, 쑥의 항염증 및 진통효과 박종철;유영법;이종호;김남재
  8. 한국영양학회지 v.31 no.4 쑥(Artemisia princeps Pampan.)추출 성분의 암세포 증식 억제효과 황윤경;김동청;황우익;한용봉
  9. J Korean Soc Food Nutr v.21 no.1 Antioxidative effectiveness of water extract and ether extract in wormwood (Artemisia montana Pampan.) Lee GD;Kim JS;Bae JO;Yoon HS
  10. Stroke v.19 The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation Pulsinelli WA;Buchan AM
  11. 中醫鍼灸經穴集成 劉冠軍
  12. 대한침구학회지 v.15 no.2 中風七穴의 중풍치료에 대한 문헌적 고찰 손인철;안성훈
  13. 中國針灸 v.14 no.2 頭穴 治療 急性 腦出血 卽刻效應的機理探討(鍼刺對體感誘發電位的影響) 東貴榮(等)
  14. 中國針灸 v.14 no.6 鍼刺對中風病人血壓及心功能的影響 王岫.
  15. 大韓鍼灸學會誌 v.16 no.2 이창현;이상룡;변덕시 고별압 치료에 상응되는 체간부 경혈에 대한 형태학적 연구
  16. 大韓鍼灸學會誌 v.10 no.1 百會 足三里穴 艾灸가 白鼠의 혈청 지질에 미치는 영향 임종국;김민규
  17. 大韓核醫學會誌 v.34 no.6 Tc-99m ECD 뇌혈류 SPECT를 이용한 百會, 人中, 合谷, 足三里, 三陰交에서 體鍼의 뇌 혈류에 대한 효과 김성민;송호천;범희승;강화정;안수기;정환정;김지열
  18. 經脈腧穴學 康鎖彬
  19. 대한약전외 한약(생약)규격집 주해서 지형준;이상인
  20. 全日本鍼灸學會誌 v.40 no.2 艾葉의 燃燒 生成物이 過酸化脂質에 미치는 작용 大西基代;戶田靜男;管田良仁;東家一雄;黑巖共一;木村通郎
  21. Maturation Phenomenon in Cerebral Ischemia Maturation of ischemic injuries observed in mongolian gerbils: introductory remarks Ito U;Yamaguchi T;Tomita H;Tone O;Shishido T;Hayashi H;Yoshida M;Ito U;Kirino T;Kuroiwa T;Klatzo I(Eds.)
  22. Progr Neurobiol v.49 Transforming growth factor-alpha (TGF-alpha) and epidermal growth factor receptor (EGF-R) in normal and pathologic brain Ferrer I;Alcantara S;Ballabriga J;Olive M;Blanco R;Rivera R;Carmona M;Berruezo M;Pitarch S;Planas AM
  23. Annu Rev Neurosci v.14 Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun Morgan JI;Curran T
  24. Neurosci Lett v.129 Sequential expression of JUN B, JUN D and FOS B proteins in rat spinal neurons: cascade of transcriptional operations during nociception Herdegen T;Tolle T;Bravo R;Zieglgansberger W;Zimmermann M
  25. J Cereb Blood Flow Metab v.13 no.6 Differential transcription and translation of immediate early genes in the gerbil hippocampus after transient global ischemia Kiessling M;Stumm G;Xie Y;Herdegen T;Aguzzi A;Bravo R;Gass P
  26. Mol Brain Res v.25 Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic ischemic injury to the young rat brain Dragunow M;Beilharz E;Sirimanne E;Lawlor P;Wiliams C;Bravo R;Gluckman P
  27. Nat Med v.3 no.3 The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo Hafezi F;Steinbach JP;Marti A;Munz K;Wang ZQ;Wagner EF;Aguzzi A;Reme CE
  28. J Cereb Blood Flow Metab v.21 no.5 Early c-Fos induction after cerebral ischemia: a possible neuroprotective role Cho S;Park EM;Kim Y;Liu N;Gal J;Volpe BT;Joh TH
  29. Brain Res v.832 no.1-2 Suppression of post-ischemic-induced foe protein expression by an antisense oligonucleotide to c-fos mRNA leads to increased tissue damage Zhang Y;Widmayer MA;Zhang B;Cui JK;Baskin DS
  30. Stroke v.26 no.9 Induction of c-fos and c-jun gene products and heat shock protein after brief and prolonged cerebral ischemia in gerbils Takemoto O;Tomimoto H;Yanagihara T
  31. Trends Neurosci v.17 Neurotrophins and brain insults Lindvall O;Kokaia Z;Bengzon J;Elmer E;Kokaia M
  32. Brain Res Brain Res Rev v.29 no.2-3 Neuron death and survival two models of hypoxic-ischemic brain damage Walton M;Connor B;Lawlor P;Young D;Sirimanne E;Gluckman P;Cole G;Dragunow M
  33. Trend in Neuroscience v.23 no.2 Is CREB a key to neuronal survival? Marshall R. Walton;Mike Dragunow
  34. Neuroscience v.105 no.3 Involvement of the brain-derived neurotrophic factor/TrkB path-way in neuroprotecive effect of cyclosporin A in forebrain ischemia Miyata K;Omori N;Uchino H;Yamaguchi T;Isshiki A;Shibasaki F
  35. J Cereb Blood Flow Metab v.14 Brain derived neurotrophic factor protects against ischemic cell damage in rat hippocampus Beck T;Lindholm D;Castren E;Wree A
  36. J Neurosci Res v.56 no.1 Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat Kiprianova I;Freiman TM;Desiderato S;Schwab S;Galmbacher R;Gillardon F;Spranger M
  37. J Cereb Blood Flow Metab v.17 Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats Schabitz WR;Schwab S;Spranger M;Hacke W