대한예방한의학회지 (Journal of Society of Preventive Korean Medicine)

대한예방한의학회 (Society of Preventive Korean Medicine)
권호 표지

Estrogen 결핍성(缺乏性) 골다공증(骨多孔症)에 미치는 산약(山藥) 추출물(抽出物)의 영향(影響)

Effects of Dioscorea batatas on Estrogen-deficient Osteoporosis

  • 황귀서 (경원대학교 한의과대학) ;
  • 이대영 (경원대학교 한의과대학)
  • Hwang Gwi-Seo (College of Oriental Medicine, Kyungwon University) ;
  • Lee Dae-Young (College of Oriental Medicine, Kyungwon University)
  • 발행 : 2003.06.29
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초록

Osteoporosis is characterized by bone loss and mobidity with osteoporotic fracture. This study was performed to evaluate the effect of on the bone mass and its related factors in estrogen-deficient animal model. The model rats of osteoporsis showed a significant decrease in bone density, bone ash density, calcium content of femur bone. At the 14th day after ovariectomy-surgery, rats were administered with DBE, extract of Dioscorea batatas, per orally, and continued for 10 weeks. And osteoporosis related parameters were determined to investigate the effect of DBE. Osteoporetic rats showed lower serum estrogen level, higher body weight than normal rats, and showed atrophy of uterine horns. DBE showed inhibitory effect on bone loss in osteoporetic condition, and reduced the increase of ALP activity and osteocalcin level in serum, and reduced the increase of OH-proline level in urine. But, DBE had no effect on cell proliferation and ALP activity in rat calvarial cell culture.

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