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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Agmatine Reduces Hydrogen Peroxide in Mesangial Cells under High Glucose Conditions

  • Lee, Geun-Taek (Department of Biochemistry, College of Science, Yonsei University) ;
  • Ha, Hun-Joo (Department of Endocrinology, College of Medicine, Yonsei University) ;
  • Lee, Hyun-Chul (Hyonam Kidney Laboratory, Soon Chun Hyang University) ;
  • Cho, Young-Dong (Department of Biochemistry, College of Science, Yonsei University)
  • Received : 2002.11.04
  • Accepted : 2002.12.09
  • Published : 2003.05.31
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Abstract

Agmatine, an amine and organic cation, reduced $H_2O_2$ that was generated by hyperglycemia, and transcription factors such as NF-${\kappa}B$ and AP-1 activity in the mesangial cells that were exposed to high glucose. However, spermine which shares a strong nucleophilic structure with agmatine decreased the $H_2O_2$ levels and AP-1, but not the NF-${\kappa}B$ activity. Possible roles for agmatine and spermine in decreasing fibronectin are discussed, and the signaling pathway for agmatine-reduced fibronectin accumulation is presented.

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References

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