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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Determining a Detectable Threshold of Signal Intensity in cDNA Microarray Based on Accumulated Distribution

  • Gao, Xia (Physics Department, Fudan University) ;
  • Fu, Xuping (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University) ;
  • Li, Tao (Shanghia Biostar Genechip Istitute) ;
  • Zi, Jian (Physics Department, Fudan University) ;
  • Luo, Yao (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University) ;
  • Wei, Qing (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University) ;
  • Zeng, Erliang (Shanghia Biostar Genechip Istitute) ;
  • Xie, Yi (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University) ;
  • Li, Yao (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University) ;
  • Mao, Yumin (State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University)
  • Received : 2003.03.27
  • Accepted : 2003.06.04
  • Published : 2003.11.30
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Abstract

In microarray data mining, one of the key problems is how to handle weak signals. Based on a bent piecewise linear accumulated distribution generally found in the microarray data, a new detectable threshold finding method is proposed to filter genes with unreliable information in this paper. More reliable and reproducible data is produced for the subsequent data mining.

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References

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