Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Human Brain GABA-T (${\gamma}$-aminobutyric acid transaminase) Inhibitory Alkaloids from Corydalis Tuber

Choi, Soo-Young;Bang, Myun-Ho;Lee, Eun-Jeong;Kwon, Oh-Shin;Kang, Tae-Cheon;Lee, Youn-Hyung;Rho, Yeong-Deok;Baek, Nam-In

  • Published : 20030600
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Abstract

The alkaloid fraction obtained from 80% MeOH extracts of Corydalis tuber showed a significant inhibitory effect on brain GABA-transaminase (GABA-T). Each alkaloid fractions using $SiO_2$ and ODS column chromatography were isolated in seven isoquinoline alkaloids. They were identified as R-(+)-stylopine, S-(-)-corydaline, R-(+)-canadine, R-(+)-tetrahydropalmatine, protopine, S-(+)-glaucine and dehydrocorydaline, based on the interpretation of several spectral data and in comparison with those of literatures. All they inhibited the activity of GABA-T.

Keywords

References

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