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Radiation-induced Tumorigenesis

  • Kim, In-Gyu (Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute) ;
  • Lee, Yun-Sil (Laboratory of Radiation Effect, Korea Institute of Radiological and Medical Sciences)
  • Published : 2003.01.31

Abstract

During the past 2 decades, radiation tumorigenesis researchers have focused on cellular and molecular mechanisms. We reviewed some of these research fields, since they may specifically relate to the induction of cancer by ionizing radiation. First, radiation-mediated mutation was discussed. Then the initiating event in radiation carcinogenesis, as well as other genetic events that may by involved, is discussed in terms of the possible role of the activation of genes and the loss of cell-cycle checkpoints.

Keywords

References

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