The Effect of Artemisia capillaris Extract on Hematological Changes in Dogs

단기간의 인진쑥 투여가 개의 혈액상에 미치는 영향

  • Published : 2003.03.01

Abstract

This study was conducted to investigate the hematological changes of the dogs when administrated excessive amount of the Artemisia capillaris extract for a short period. In this experiment, clinically healthy dogs(n = 20, average weight = 7.68 kg) were divided into 2 groups : Artemisia capillaris rude juice extract group(CR) and concentrated extract group(CE). They were inserted stomach tube and administrated the extracts (5 ml/kg) for 8 days. The followings are the results of this experiment.: 1). The number of red blood cell(RBC) was significantly (p<0.05) decreased in CE group on day 4, 5, 6, whereas CJE group showed significantly (p<0.05) difference on day 5. 2). The packed cell volume(PCV) and hemoglobin concentration were significantly (p<0.05) decreased in both groups during experimental periods. 3). The met hemoglobin was significantly (p < 0.05) increased from 12 hrs after administration to day 8 in CJE group wheres, it was significantly (p<0.05) increased on day 6,7 in CE group.

Keywords

References

  1. Vet Med v.135 Normal blood values in the beagle Anderson AC;Gee W(et al.)
  2. J Lab Clin Med v.61 Improved method for the determination of blood glutathione Beutler E;Duran O;Kelly BM(et al.)
  3. Aust Vet Practit v.26 Six cases of Heinz body haemolytic anemia induced by onion and/or garlic ingestion Edwards CB;Belford CJ(et al.)
  4. Blood v.65 Glutathione-dependent-protection against oxidative damage of the humans red cell membrane Fujise H;Dale GL;Beutler E(et al.)
  5. J Comp Patho Ther v.22 Onion poisoning in cattle Gold smith WW(et al.) https://doi.org/10.1016/S0368-1742(09)80034-9
  6. Am J Med Sci v.181 Anemia in dogs produced by feeding of the whole onions and of onion products Gruzhit OM(et al.) https://doi.org/10.1097/00000441-193106000-00007
  7. J Bio Chem v.249 Glutathione S?transferases Habig W.H.;Pabst M.J.(et al.)
  8. Kor J Pharmacog v.4 Studies on the Volatile Oil Constituents in Artemisia sp. Isolation and Determination of Camhor by Gas Chromatography Hahn DR;Kim IH(et al.)
  9. Vet Pathol v.22 Experimental onion-induced hemolytic anemia in dogs Harvey J.W.;Rackear D(et al.) https://doi.org/10.1177/030098588502200414
  10. Kor Nutr Soc v.31 Inhibitory effect of Artemisia princeps Pampan. Extract on Growth of Cancer Cell Lines Hwang YK;Kim DC;Hwang WI;Han YB
  11. Kor J Pharmacogn Some Coumarins from Artemisia keiskeana (Compositae) Jang WY;Kwak JH(et al.)
  12. Kor Soc Food Sci Nutr Effects of Scoparone and Artemisia asiatica Nakai on the function of Liver Joo MK;Choi SK(et al.)
  13. Kor J Food Sci Technol v.27 Studies on the Physiological Functionality of Pine Needle and Mugwort Extracts Kang YH;Park YK;Oh SR;Moon KD
  14. JAVMA v.156 Hemolytic anemia in sheep fed wild onion (Allium validum) Kent R.;Van K.;Lynn F.;James A.;Earl Johnson MS.
  15. J Vet Clin v.18 Hematological changes in dogs administrated excessive amount of water celery concentrated extracts Kim HT;Lee KW(et al.)
  16. J Vet Clin v.18 Hematological changes in dogs administrated excessive amount of water celery crude juices Kim HT;Lee KW(et al.)
  17. J Vet Clin v.19 The hematological effect of excessive crude Allium tuberosum extract administrated in large dogs Kim JW(et al.)
  18. J Kor Soc Food Sci Nutr v.25 Efects of Artemisia selengensis Methanol Extract on Ethanol? Induced Hepatotoxicity in Rat Liver Kim KS;Lee MY(et al.)
  19. Agricultural Chemistry and Biotechnology v.37 Volatile components Artemisia apiaceae Herba Kim OC;Jang HJ(et al.)
  20. Am J Vet Res v.40 Effects of feeding cull domestic onions(Allium cepa) to sheep Kirk JH;Bulgin MS(et al.)
  21. Feline Fract v.11 Onion poisoning in the cat Kobayashi K(et al.)
  22. Kor J Food SCI ANI Resour v.19 Effect of Mugwort-water Extracts on Cadmium Toxicity in Rats Lee CH;Han KH;Choi IS;Kim CY;Cho JK
  23. Kor Nutr Soc v.29 Effect of Mugwort on Inhibition of the Duodenal Ulcer Induced by Cysteamine Administration Lee JY;Lee SS(et al.)
  24. J Vet Clin v.16 Hematological changes in dogs administrated excessive galic-extracts Lee KW(et al.)
  25. AJVR v.61 Hematologic changes associated with the appearance of eccentrocytes after intragastric administration of garlic extract to dogs Lee KW;Yamato O;Tajima M(et al.) https://doi.org/10.2460/ajvr.2000.61.1446
  26. Kor Nutr Soc v.30 Effect of Artemisia Princeps var Orientalis and Circium Japonicum var Ussuriense on Liver Function, Body Liquid and Bile Acid of Hyperlipidemic Rat Lim SS;Kim MH;Lee JH(et al.)
  27. Kor Nutr Soc v.30 Biological Activity of the soluble extracts from Artemisia princeps var orientalis Acted on Cardiovascular system Lim SS;Lee JH(et al.)
  28. Kor Nutr Soc v.30 Effect of Artemisia Princeps Var Orientalis and Circium Japonicum Var Ussuriense on Serum Lipid of Hyperlipidemic Rat Lim SS;Lee JH(et al.)
  29. JAVMA v.200 Hematologic effects and feeding performance in cattle fed cull domestic onions(Allium cepa) Lincoln SD;Howell ME;Combs JJ;Hinman DD
  30. Blood v.73 Elevated glutathione accelerates oxidative damage to erythrocytes produced by aromatic, disulfide Maede Y;Kuwabara M(et al.)
  31. J Agric Food Chem v.42 Comparative toxicity of prop(en)yl disulfides derived from alliaceae: possible involvement of 1-propenyl disulfides in onion-induced hemolytic anemia Munday R;Manns E(et al.) https://doi.org/10.1021/jf00040a023
  32. St. Marianna Med J v.8 Microdetermination of methemoglobin and the normal value Nakamura I;Nishid N;Maruyama H(et al.)
  33. J Kor Soc Food Sci Nutr v.27 Effects of Artemisia iwayomogi Kitamura Ethanol Extract on Lowering Serum and Liver Lipids in Rats Nam SM;Ham SS(et al.)
  34. Jpn J Vet Sci v.48 Effect of onion ingestion on anti oxidizing agents in dog erythrocytes Ogawa E;Shinoki T;Akahori F;Masaoka T https://doi.org/10.1292/jvms1939.48.685
  35. J Vet Clin v.19 Hematological Effect of Administration Excessive Amount of the Korean Native Chinese Chive Extracts in Small Dogs Oh HW(et al.)
  36. J Kor Soc Food Nutr v.23 Studies on the Chemical Components and Biological Activities of Edible Plants in Korea(Ⅵ) Park JC;Yu YB;Lee H;Kim NJ
  37. JAVMA v.160 Acute hemolytic anemia caused by wild onion poisoning in horses Pierce KR;Joyce JR;England RB;Jones LP
  38. Kor J Medicinal Crop Sci v.1 Growth Characteristics and Chemical Components in Local Collections of Artemisia sp Rho TH;Seo GS(et al.)
  39. Public Health Rep v.45 An anemia in dogs produced by feeding onions Sebrell WH(et al.) https://doi.org/10.2307/4579656
  40. Pharmacol Ther v.47 Glutathione?dependent protection against oxidative injury Shan XQ;Jones DP(et al.) https://doi.org/10.1016/0163-7258(90)90045-4
  41. J Am Vet Med Assoc v.94 Onion poisoning in horses Thorp F;Harshifield GS(et al.)
  42. Vet Rec v.117 Onion poisoning of young cattle Verhoeff J;Hajer R(et al.) https://doi.org/10.1136/vr.117.19.497
  43. Vet Rec v.142 Induction of onion induced haemolytic anemia in dogs with sodium n-propylthio-sulfate Yamato O;Hayashi M;Maede Y(et al.) https://doi.org/10.1136/vr.142.9.216
  44. 한국농화학회, 춘계학술발표초록집 인진쑥의 생리학적 물질탐색에 관한 연구 정성원;김은정;함승시;정차권