Toxicological Research

  • 제19권1호
  • /
  • Pages.73-82
  • /
  • 2003
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

랫드에서 방풍, Saposhnikovia divaricata (Turcz.) Schischk의 피하투여 독성에 대한 연구

Subcutaneous Toxicity Study of Saposhnikovia divaricata (Turcz.) Schischk in Rats

  • 이영순 (서울대학교 수의과대학 공중보건학교실) ;
  • 조성대 (서울대학교 수의과대학 공중보건학교실) ;
  • 안남식 (서울대학교 수의과대학 공중보건학교실) ;
  • 정지원 (서울대학교 수의과대학 공중보건학교실) ;
  • 양세란 (서울대학교 수의과대학 공중보건학교실) ;
  • 박준석 (서울대학교 수의과대학 공중보건학교실) ;
  • 박기수 (서울대학교 수의과대학 공중보건학교실) ;
  • 홍인선 (서울대학교 수의과대학 공중보건학교실) ;
  • 서민수 (서울대학교 수의과대학 공중보건학교실)
  • 발행 : 2003.03.01
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초록

To evaluate influence of Saposhnikovia divaricata (Turcz.) Schischk extract on rat, Saposhnikovia divaricata (Turcz.) Schischk extract was diluted with 0.9% saline (100 mg/ml/kg, 10 mg/ml/kg, and 1 mg/ml/kg, respectively), and each of diluted test material extract was daily treated subcutaneously for 4 weeks and single-treated subcutaneously for 2 weeks. There were no significances in body weight analysis, urinary analysis, and ophthalmological test. However, in serum biochemical analysis and hematological analysis, we found some significances in high and middle dose group compared with control group. These significances in serum biochemical analysis and hematological analysis may be not induced by test material, because it was not found to be significant from control group in histopathological examination. Therefore, it was concluded that NOEL (No Observed Effect Level) of test material extract may be higher than all treatment doses used in this study, and Saposhnikovia divaricata (Turcz.) Schischk extract may be a non-toxic material.

키워드

참고문헌

  1. Zhongguo zhong Yao Za Zhi v.14 no.10 Herbalogic studies on the chinese drug fang feng Zhong Yao Tong Bao
  2. 경의한의대논문집 v.19 no.2 방풍의 규격화에 관한 연구(A Study on The Standardization of Bang-Poong(방풍)) 이상인;서영배;최호영
  3. Zhong Yao Tong Bao v.10 no.12 Technics for cultivating Saposhnikovia divaricata Zhongguo;Zhong Yao;Za Zhi
  4. Zhongguo Zhong Yao Za Zhi v.26 no.2 Studies on chemical constituents from roots of Saposhnikovia divaricata (Turcz.), Schischk Xiao,Y.Q.;Li,L.;Yang,B.;huang,L.Q.
  5. Zhongguo Zhong Yao Za Zhi v.24 no.11 GC-MS analysis of essential oils from the roots of Saposhnikovia divaricata (Turcz.) schischk Ji,L.;Pan,J.;Yang,J.;Xiao,Y.
  6. Chem Pharm Bull v.37 no.5 The major pectic arabinogalactan having activity on the reticuloendothelial system from the roots and rhizomes of Saposhnikovia divaricata Shimizu,N.;Tomoda,M.;Gonda,R.;Kanari,M.;Takanashi,N.;Takakhashi,N. https://doi.org/10.1248/cpb.37.1329
  7. Chem Pharm Bull v.49 no.2 Analgesic components of saposhnikovia root (Saposhnikovia divaricata) Okuyama,E.;Hasegawa,T;Matsushita,T.;Fujimoto,H.;Ishibashi,M.;Yamazaki,M. https://doi.org/10.1248/cpb.49.154
  8. Zhong Xi Yi Jie He Za Zhi v.11 no.12 Comparative studies on the febrifugal analgesic and anticonvulsive activities of water extracts from cultivated and wild Saposhnikovia divaricata Wang,F.R.;Xu,Q.P.;Li,P.
  9. Zhong Yao Tong Bao v.13 no.6 Pharmacologic studies on the root of Saposhnikovia divaricata (Turcz.) Schischk Tang,R.J.;Min,Z.H.;Xu,C.Y.
  10. 대한침척학회지 v.3 no.1 방풍수침(防風水鍼)이 진통 소염 해열 및 진경(鎭痙)에 미치는 영향 강성길;이종국
  11. Jpn. J. Pharmacol v.85 no.4 Inhibitory potential of herbal medicines on human cytochrome P450-mediated oxidation: properties of umbelliferous or citrus crude drugs and their relative prescriptions Guo,L.Q.;Taniguchi,M.;Chen,Q.Y.;Baba,K.;Yamazoe,Y. https://doi.org/10.1254/jjp.85.399
  12. Planta Med v.66 no.7 Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium Wang,C.N.;Shiao,Y.J.;Kuo,Y.H.;Chen,C.C.;Lin,Y.L. https://doi.org/10.1055/s-2000-8624