Effect of Foilum mori on Adipocyte Differentiation

  • Lee, Geun-Won (School of Chemical Engineering and Biotechnology, Ajou University) ;
  • Byun, Sang-Yo (School of Chemical Engineering and Biotechnology, Ajou University)
  • 발행 : 2003.10.01

초록

Several natural products were tested to control the differentiation of cultured human mesenchymal stem cell into adipocyte. The extent of the inhibitory effect on the conversion of adipose was measured using Oil red O staining, which stains accumulated lipid droplets in the cytoplasm of adipocyte. Of the various natural product extracts, the adipocyte differentiation was inhibited by an extract from Folium mori in the concentration range 1${\times}$10$\^$-4/∼5${\times}$l0$\^$-2/ g/mL. These results suggest that Folium mori has an inhibitory activity toward the adipose conversion, which is a major cause of obesity.

키워드

참고문헌

  1. Science v.284 Multilineage potential of adult Human mesenchymal stem cells Pittenger,M.F.;D.R.Marshak https://doi.org/10.1126/science.284.5411.143
  2. Annu. Rev. Nutr. v.12 Cellular and molecular aspects of adipose tissue development Ailhaud,G.;P.Grimaldi,R.Negrel https://doi.org/10.1146/annurev.nu.12.070192.001231
  3. Biochemistry v.97 Quantitation of adipose conversion nd triglycerides by staining intracytoplasmic lipids with Oil red O Ramirez Zacarias,J.L.;W.Kuri Harcuch
  4. FEBS Lett. v.475 Bone morphogenetic protein-2 stimulates adipogenic differentiation of mesenchymal precursor cells in synergy with BRL 49653 (rosiglitazone) Sottile,V.;K.Seuwen https://doi.org/10.1016/S0014-5793(00)01655-0
  5. J. Biol. Chem. v.254 Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion Wise,L.S.;H.Green
  6. Cell v.14 Interruption of the adipose conversion of 3T3 cells by biotin deficieny: differentiation without triglyceride accumulation Kuri Harcuch,W.;H.Green https://doi.org/10.1016/0092-8674(78)90300-8
  7. J. Biol. Chem. v.257 Hormonal regulation of stearoyl coenzyme A desaturase activity and lipogenesis during adipose conversion Kasturi,R.;V.C.Joshi
  8. J. Supramole. Structure v.14 Inhibition of adipose conversion in 3T3-L2 cells by retionoic acid Murray,T.;T.R.Russell https://doi.org/10.1002/jss.400140214
  9. Proc. Nat. Acad. Sci. USA v.82 Typeβ transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts Ignotz,R.A.;J.Massague https://doi.org/10.1073/pnas.82.24.8530
  10. Comp. Biochem. Physiol. v.96A Comparative investigation of vitamins and their analogues on terminal differentiation, from preadipocytes to adipocytes, of 3T3-L1 cells Kawada,T.;N.Aoki;Y.Kamei;E.Sugimoto
  11. Proc. Nat. Acad. Sci. USA v.6 Adipogenic and anti-adipogenic factors in the pituitary and other organs Hayashi,I.;T.Nixon;M.Morikawa;H.Green
  12. J. Cell Sci v.106 Proadipocyte cell lines: Models of cellular proliferation and differentiation Miriam,J.S.;L.S.Rodney;W.Walker
  13. Korean J. Seric. Sci. v.43 Cytotoxicity of the ethanol extracts of mulberry leaves, branches and silkworn feces Ahn,M.Y.;Y.K.Lee
  14. Bull. K. H. Pharma. Sci. v.28 Antidiabetic effect and mechanism of Mori Folium on streptozotocin-induced diabetic mouse Lee,K.H.;S.H.Chung
  15. Diabetes Care v.24 Deterioration of the metabolic risk profile in women: Respective contributions of impaired glucose tolerance and visceral fat accumulation Pascot,A. https://doi.org/10.2337/diacare.24.5.902