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Effect of Seatangle Oligosaccharide Drink on Oxidation of Serum Lipid and Bleeding and Plasma Clotting Time in Rats Fed a Hyperlipidemic Diet

해조 올리고당 음료가 고지혈증 유도 쥐에 있어서 혈액 지질 산화 및 혈액ㆍ혈장 응고에 미치는 영향

  • 주동식 (동해대학교 외식산업학과) ;
  • 이진경 (강릉대학교 동해안해양생물자원연구센터) ;
  • 김옥선 (강릉대학교 동해안해양생물자원연구센터) ;
  • 조순영 (강릉대학교 동해안해양생물자원연구센터) ;
  • 이득식 (동해대학교 외식산업학과) ;
  • 제외권 (동명대학 식품가공과) ;
  • 최종원 (경성대학교 약학대학)
  • Published : 2003.12.01

Abstract

We investigated the effect of seatangle drink and seatangle extract on lipid oxidation, blood coagulation and intestinal movement in rats fed a hyperlipidemic diet. In the dietary hyperlipidemic induced group, the serum superoxide dismutase activity decreased and formation of hydroxy radical increased when compared to normal group, but these were controlled by seatangle drink treatment. The decreased of bleeding time and increased of tissue factor in the dietary hyperlipidemic rats were regulated by seatangle drink and seatangle extract, and especially the activity of tissue factor was remarkably decreased. Seatangle drink and seatangle extract were increased contraction on intestinal movement. Therefore, it can be concluded that seatangle drink or seatangle extract treatment depresses changing in absorption of gastrointestinal track in rats fed a hyperlipidemic diet.

식이성 고지혈증 model 실험동물을 사용하여 해조 음료를 투여하여 지질 산화와 관련된 효소 변화 및 혈액응고에 미치는 영향을 시험하였다. 혈액의 lipid peroxide 함량과 혈중 hydroxy radical 생성이 식이성 고지혈증의 유도로 증가되었으며, 혈중 superoxide dismutase의 활성은 오히려 감소되던 것이 해조 음료의 투여로 조절되었다. 식이성 고지혈증을 유도한 흰쥐에서 감소되었던 bleeding time과 plasma clotting time이 해조 음료의 투여로 다소 증가하였고, 증가하였던 tissue factor의 활성은 현저히 감소되었다 동물 소화장관에 대한 운동성 시험에서는 해조 음료의 투여로 장관 운동이 증가되는 것을 확인하였다. 이러한 결과는 해조 음료나 해조 음료 소재에 다량 함유되어 있는 해조 올리고당이 기존의 해조 다당과 마찬가지로 혈관계 관련 질병의 예방에 유효한 기능을 할 수 있다는 것을 나타내며 향후로도 다양한 기능성 제품의 소재가 될 수 있을 것으로 여겨진다.

Keywords

References

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