Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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A DNA Strand-Nicking Principle of a Higher Plant, Caesalpinia sappan

  • Mar, Woongchon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Lee, Hyun-Tai (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University) ;
  • Je, Kang-Hoon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Choi, Hye-Young (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University) ;
  • Seo, Eun-Kyoung (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University)
  • Published : 2003.02.01
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Abstract

To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.

Keywords

References

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