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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Immunosuppressive Activity of Novel Succinylacetone Analogues

  • Kim, Taek-Hyeon (Department of Applied Chemistry, College of Engineering, Chonnam National University) ;
  • Oh, Dong-Ryun (Department of Applied Chemistry, College of Engineering, Chonnam National University) ;
  • Na, Hee-Sam (Department of Microbiology, Chonnam National University Medical School) ;
  • Lee, Hyun-Chul (Department of Microbiology, Chonnam National University Medical School)
  • Published : 2003.03.01
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Abstract

This study describes the synthesis of novel enol esters (3) and triketones (4) as analogues of succinylacetone (SA) (Ed- this abbreviation is introduced here based on your use of it in the body of the paper) and the evaluation on the mouse allogeneic mixed lymphocyte reaction (MLR) and the murine model of antigen-induced paw edema formation for immunosuppressive activity. Enol esters (3a-f) were about 2-4 fold more potent than SA in in vitro activity.

Keywords

References

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