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The Pharmaceutical Society of Korea (대한약학회)
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DNA Topoisomerases I and II Inhibitory Activity of Constituents Isolated from Juglans mandshurica

  • Li, Gao (College of Pharmacy, Yeungnam University) ;
  • Lee, Sun-Young (Department of Biochemistry, College of Natural Sciences, Yeungnam University) ;
  • Lee, Kyeung-Seon (College of Pharmacy, Yeungnam University) ;
  • Lee, Sung-Won (College of Pharmacy, Yeungnam University) ;
  • Kim, Sang-Hyun (College of Pharmacy, Yeungnam University) ;
  • Lee, Seung-Ho (College of Pharmacy, Yeungnam University) ;
  • Lee, Chong-Soon (Department of Biochemistry, College of Natural Sciences, Yeungnam University) ;
  • Woo, Mi-Hee (College of Pharmacy, Catholic University) ;
  • Son, Jong-Keun (College of Pharmacy, Yeungnam University)
  • Published : 2003.06.01
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Abstract

Nine diarylheptanoids (1-9), one triterpene (10), one sesquiterpenoid (11), one naphthoquinone (12), four tetralones (13-16), one naphthalene carboxylic acid glucoside (17) and six naphthalenyl glycosides (18-23) were isolated from the roots of Juglans mandshurica Maximowicz (Juglandaceae), and their structures determined from the chemical and spectral data. Here, we report the inhibitory effects, on the DNA topoisomerases I and II activities, of all these compounds. Compounds 10 and 23 showed more potent inhibitory effects, on the DNA topoisomerases I and II (94.0 and 86.0% inhibitions at the concentration of 5 $\mu$ g/mL, respectively), than the positive control compounds, camptothecin and etoposide.

Keywords

References

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