Archives of Pharmacal Research

  • 제26권7호
  • /
  • Pages.532-534
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  • 2003
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

${\gamma}-Pyrone$ Derivatives, Kojic Acid Methyl Ethers from a Marine-Derived Fungus Altenaria sp.

  • Li, Xifeng (Department of Chemistry, Pukyong National University) ;
  • Jeong, Jee-Hean (R＆D Center, Coreana Cosmetics Co. Ltd.) ;
  • Lee, Kang-Tae (R＆D Center, Coreana Cosmetics Co. Ltd.) ;
  • Rho, Jung-Rae (Marine Natural Products Laboratory, Korea Ocean Research ＆ Development Institute) ;
  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Kang, Jung-Sook (College of Dentistry, Pusan National University) ;
  • Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
  • 발행 : 2003.07.01
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초록

Kojic acid dimethyl ether (1), and the known kojic acid mono methyl ether (2), kojic acid (3) and phomaligol A (4) have been isolated from the organic extract of the broth of the marine-derived fungus Altenaria sp. collected from the surface of the marine green alga Ulva pertusa. The structures were assigned on the basis of comprehensive spectroscopic analyses. Each isolate was tested for its tyrosinase inhibitory activity. Kojic acid (3) was found to have significant tyrosinase inhibitory activity, but compounds 1, 2, and 4 were found to be inactive.

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참고문헌

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