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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and $PGE_2$ Inhibitory Activity of Vinylated and Allylated Chrysin Analogues

  • Published : 2003.08.01
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Abstract

Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2 -hydroxy-3 -iodo-4 ,6 -dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and 8) showed moderate inhibitory activities of $PGE_2$ production from LPS-induced RAW 264.7 cells.

Keywords

References

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