Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Controlled Release of Epidermal Growth Factor (EGF) from EGF-loaded Polymeric Nanoparticles Composed of Polystyrene as Core and Poly(methacrylic acid) as Corona in vitro

  • Park, In-Kyu (School of Agricultural Biotechnology, Seoul National University) ;
  • Seo, Seog-Jin (School of Agricultural Biotechnology, Seoul National University) ;
  • Akashi, Mitsuru (Graduate School of Engineering, Osaka University) ;
  • Akaike, Toshihiro (Department of Biomolecular Engineering, Tokyo Institute of Technology) ;
  • Cho, Chong-Su (School of Agricultural Biotechnology, Seoul National University)
  • Published : 2003.08.01
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Abstract

Polymeric nanoparticles composed of polystyrene (PS) as core and poly(methacrylic acid) (PMA) as corona were prepared by the dispersion copolymerization. The potential of the nanoparticles as carriers for recombinant human epidermal growth factor (EGF) was investigated. The nanoparticles showed monodispersity and good water-dispersibility. The loading content of EGF to the nanoparticles was very high due to electrostatic interaction between EGF and nanoparticles. EGF was released as a pseudo-zero order pattern after initial burst effect. The nanoparticles were sufficient for A431 cells proliferation.

Keywords

References

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