Microbial Metabolism of the Environmental Estrogen Bisphenol A

  • Yim, Soon-Ho (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) ;
  • Kim, Hyun-Jung (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) ;
  • Lee, Ik-Soo (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
  • Published : 2003.10.01


Preliminary microbial metabolism studies of bisphenol A (BPA) (1) on twenty six microorganisms have shown that Aspergillus fumigatus is capable of metabolizing BPA. Scale-up fermentation of 1 with A. fumigatus gave a metabolite (2) and its structure was established as bisphenol $A-O-{\beta}-D-glucopyranoside$ (BPAG) based on spectroscopic analyses.



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