Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics (대한후두음성언어의학회지)

The Korean Society of Laryngology, Phoniatrics and Logopedics. (대한후두음성언어의학회)
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Spasmodic Dysphonia Induced by Valproic Acid

Valproic Acid 복용에 의해 유발된 연축성 발성장애 1예

  • 오지영 (이화여자대학교 의과대학 신경과학교실) ;
  • 조현지 (이화여자대학교 의과대학 신경과학교실) ;
  • 박기덕 (이화여자대학교 의과대학 신경과학교실) ;
  • 정성민 (이화여자대학교 의과대학 이비인후과학교실)
  • Published : 2003.06.01
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Abstract

Spasmodic dysphonia is a task-specific dystonia affecting the laryngeal muscles, resulting forced, strained voice. The pathophysiologic mechanism is not fully understood. We experienced a patient with epilepsy developed transient spasmodic dysphonia during valproic acid monotherapy. The spasmodic dysphonia resolved with dose reduction of valproic acid. Change of neurotransmitters, such as GABA in basal ganglia or blockade of sodium channel is possible mechanism in our case of drug-related spasmodic dysphonia.

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