Archives of Pharmacal Research

  • 제26권11호
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  • Pages.912-916
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  • 2003
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Triterpenoids from Schisandra henryi with Cytotoxic Effect on Leukemia and Hela Cells In Vitro

  • Chen, Ye-Gao (Department of Chemistry, Yunnan Normal University) ;
  • Wu, Zheng-Cai (Department of Traditional Chinese Herbs, Yunnan Institute of Traditional Chinese Medicine) ;
  • Lv, Yu-Ping (Department of Chemistry, Yunnan Normal University) ;
  • Gui, Shi-Hong (Department of Chemistry, Yunnan Normal University) ;
  • Wen, Jin (Department of Chemistry, Yunnan Normal University) ;
  • Liao, Xin-Rong (Department of Traditional Chinese Herbs, Yunnan Institute of Traditional Chinese Medicine) ;
  • Yuan, Li-Ming (Department of Chemistry, Yunnan Normal University) ;
  • Halaweish, Fathi (Department of Chemistry & Biochemistry, South Dakota State University)
  • 발행 : 2003.11.01
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초록

Four known lanostane triterpenoids, schiprolactone A (1), schisanlactone B (2), nigranoic acid (3) and schisandronic acid (4) Were isolated from the stems of Schisandra henryi for the first time. Their structures were characterized by IR, MS and NMR techniques. Compounds 1, 2 and 4 showed moderate cytotoxic activity against Leukemia cells in vitro. Cytotoxic activity of compounds 1-4 showed $IC_{50}$ of 0.0097, 0.01, 0.097 and 0.0099 $\mu$ mol/mL respectively toward Leukemia cells and $IC_{50}$ of 0.097, 0.1, 0.097 and 0.099 $\mu$mol/mL toward Hela cells respectively. It is the first report that these compounds possess cytotoxic activity on Leukemia and Hela cells.

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