QSAR Study for Cytotoxicity of Alkylphenols on HeLa Cell

알킬페놀 화합물의 HeLa cell (HL-60)의 세포독성에 대한 QSAR 연구

  • 김명길 (경기도 보건환경연구원) ;
  • 김재현 (동덕여자대학교 자연과학대학 보건관리학과)
  • Published : 2003.12.01

Abstract

The purpose of the present study was to perform experiments of cytotoxicity using HeLa cell and to evaluate the possibility that QSAR is applicable to the cytotoxicity of alkylphenols. Higher toxicities were found in four alkylphenols in the following order: 4-n-Nonylphenol) 4-tert-Octylphenol) 4-n-Octylphenol > 4-n Heptylpheonl. Whereas other alkylphenols were apparently less toxic. By using Percent Hydrophilic Surface Area (PHSA) quantitative structure-activity relationships (QSARs) models were developed: Cytotoxicity (%) = 90.14089-4.72224 PHSA ($R^2$=0.2046, $\alpha$=0.0265). It is concluded that some of the obtained data are useful to determine whether QSAR methods can be of general use in predicting that until further work is undertaken to develop QSARs for a much wider range of homologous series of alkylphenol compounds.

Keywords

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